INT25943

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Context Info
Confidence 0.53
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.79
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
brains 1
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 4 100.00 Very High Very High Very High
dexamethasone 4 99.30 Very High Very High Very High
Morphine 8 98.50 Very High Very High Very High
anesthesia 2 96.12 Very High Very High Very High
Opioid 2 71.56 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 12 100.00 Very High Very High Very High
Cognitive Disorder 4 98.40 Very High Very High Very High
Dementia 2 94.84 High High
Disease 4 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As such, the effect of anesthetics on APP protein and mRNA levels was assessed utilizing semiquantitative Western-immunoblot and reverse transcription polymerase chain reaction (RT-PCR) in brains of rats following intraperitoneal treatment with propofol and thiopental.
Transcription (levels) of APP in brains
1) Confidence 0.53 Published 2005 Journal Neurochem. Res. Section Abstract Doc Link 16258851 Disease Relevance 0.45 Pain Relevance 0.10
In contrast, in the applied single dosage chronic morphine treatment did not influence either the APP and BACE protein levels or the APP mRNA production.
Transcription (production) of APP associated with morphine
2) Confidence 0.53 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.24 Pain Relevance 0.41
A concomitant 25% increase was found both in the beta-secretase (BACE) and APP mRNA levels (108%).
Transcription (levels) of APP
3) Confidence 0.53 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.26 Pain Relevance 0.41
The anesthetics did not change cortical APP protein and mRNA concentration considerably.
Transcription (concentration) of APP
4) Confidence 0.47 Published 2005 Journal Neurochem. Res. Section Abstract Doc Link 16258851 Disease Relevance 0.40 Pain Relevance 0.09
In contrast, TPA, forskolin, and dexamethasone showed little or no effect on the abundance of amyloid beta-protein precursor mRNA.
Transcription (abundance) of amyloid beta-protein associated with alzheimer's dementia and dexamethasone
5) Confidence 0.42 Published 1989 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2544164 Disease Relevance 0.25 Pain Relevance 0.17
Phorbol ester regulates the abundance of enkephalin precursor mRNA but not of amyloid beta-protein precursor mRNA in rat testicular peritubular cells.
Transcription (abundance) of amyloid beta-protein associated with alzheimer's dementia and enkephalin
6) Confidence 0.32 Published 1989 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 2544164 Disease Relevance 0.19 Pain Relevance 0.27

General Comments

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