INT259446

Context Info Confidence 0.28 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

mitochondrion (Cyp11a1)

Anatomy Link Frequency brain 2 Cyp11a1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 1 5.00

Disease Link Frequency Relevance Heat Smith-lemli-opitz Syndrome 6 30.96 Skin Cancer 6 5.00 Malignant Neoplastic Disease 2 5.00 Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Very low expression of P450scc has also been detected in brain [7], kidney [8], gut [9], and skin [10]–[12], indicating production of pregnenolone at these sites for local use.

Positive_regulation (detected) of Gene_expression (expression) of P450scc in brain

1) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0 Pain Relevance 0

General Comments

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