INT259451

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.30 Pain Relevance 0

cell differentiation (DHCR7) mitochondrion (Cyp11a1) small molecule metabolic process (DHCR7) oxidoreductase activity (DHCR7) endoplasmic reticulum (DHCR7)

DHCR7 (Homo sapiens) Cyp11a1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 1 5.00

Disease Link Frequency Relevance Heat Smith-lemli-opitz Syndrome 6 100.00 Skin Cancer 6 5.00 Malignant Neoplastic Disease 2 5.00 Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The latter suggests an in vivo action of P450scc on 7DHC, at least under the pathological condition of SLOS.

SLOS Binding (condition) of P450scc associated with smith-lemli-opitz syndrome

1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0.30 Pain Relevance 0

General Comments

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