INT259452

Context Info Confidence 0.25 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0

mitochondrion (STAR, Cyp11a1) lipid binding (STAR) transport (STAR) small molecule metabolic process (STAR)

Anatomy Link Frequency adrenal cortex 1 STAR (Homo sapiens) Cyp11a1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 1 5.00

Disease Link Frequency Relevance Heat Smith-lemli-opitz Syndrome 6 58.24 Skin Cancer 6 5.00 Malignant Neoplastic Disease 2 5.00 Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus the StAR protein provides a likely carrier for transport of 7DHC to the inner mitochondrial membrane of the adrenal cortex for its metabolism by P450scc.

StAR Binding (metabolism) of P450scc in adrenal cortex

1) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.