INT25953

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Context Info
Confidence 0.42
First Reported 1989
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 5.91
Pain Relevance 8.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 8
satellite cells 4
microglia 4
nerves 2
respiratory 2
Ptger2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 322 100.00 Very High Very High Very High
narcan 3 100.00 Very High Very High Very High
Inflammatory mediators 69 99.98 Very High Very High Very High
agonist 150 98.70 Very High Very High Very High
Serotonin 2 98.60 Very High Very High Very High
COX2 207 98.24 Very High Very High Very High
gABA 12 98.22 Very High Very High Very High
bradykinin 40 97.64 Very High Very High Very High
Kappa opioid receptor 4 97.12 Very High Very High Very High
Opioid 4 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 460 99.78 Very High Very High Very High
Toxicity 19 99.52 Very High Very High Very High
Colitis 6 96.96 Very High Very High Very High
Depression 2 90.40 High High
Disease 118 88.76 High High
Ganglion Cysts 16 86.92 High High
Headache 150 75.00 Quite High
Nervous System Injury 2 75.00 Quite High
Neuropathic Pain 13 72.60 Quite High
Neurogenic Inflammation 10 68.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As stimulants, BK at 10(-5) M (n=9) and 10(-6) M (n=4) and BK in equimolar combination with histamine (HA) and serotonin (5-HT; 10(-5) M: n=8, 10(-6) M: n=6, 10(-7) M: n=6) dose-dependently increased PGE2 release.
Positive_regulation (increased) of Localization (release) of PGE2 associated with serotonin and bradykinin
1) Confidence 0.42 Published 1998 Journal Life Sci. Section Abstract Doc Link 9627103 Disease Relevance 0.32 Pain Relevance 0.61
This would suggest that enhanced secretion of PGE2 through NE might increase microglial toxicity.
Positive_regulation (enhanced) of Localization (secretion) of PGE2 associated with toxicity
2) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.60 Pain Relevance 0.18
We further investigated whether the augmentation of COX-2 synthesis by NE in the presence of LPS is accompanied by an increased release of PGE2, an important product of the enzymatic activity of COX-2 (Fig. 3).
Positive_regulation (increased) of Localization (release) of PGE2
3) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0
Considering the total amount of PGE2 secreted the combination of inflammatory mediators caused a significantly greater release of PGE2 at 10(-5) and 10(-6) M (p<0.01, Kruskal-Wallis test) than BK stimulation alone.
Positive_regulation (caused) of Localization (release) of PGE2 associated with inflammatory mediators and bradykinin
4) Confidence 0.37 Published 1998 Journal Life Sci. Section Abstract Doc Link 9627103 Disease Relevance 0.33 Pain Relevance 0.56
We observed a significant increase in the secretion of PGE2 after 8 h of stimulation with the combination of LPS (10 ng/ml) and NE (1 ?
Positive_regulation (after) of Localization (secretion) of PGE2
5) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0
We observed a significant increase in the secretion of PGE2 after 8 h of stimulation with the combination of LPS (10 ng/ml) and NE (1 ?
Positive_regulation (stimulation) of Localization (secretion) of PGE2
6) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0
We observed a significant increase in the secretion of PGE2 after 8 h of stimulation with the combination of LPS (10 ng/ml) and NE (1 ?
Positive_regulation (increase) of Localization (secretion) of PGE2
7) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0
This would suggest that enhanced secretion of PGE2 through NE might increase microglial toxicity.
Spec (might) Positive_regulation (increase) of Localization (secretion) of PGE2 associated with toxicity
8) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.59 Pain Relevance 0.18
NE increases release of PGE2 by LPS-stimulated primary microglial cells
Positive_regulation (increases) of Localization (release) of PGE2 in microglial cells
9) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0
Our study shows that NE increases LPS-induced COX-2 expression and PGE2 secretion by primary rat neonatal microglia in vitro.
Positive_regulation (induced) of Localization (secretion) of PGE2 in microglia
10) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.68 Pain Relevance 0.46
The peptide did not further increase PGE2 and TXB2 release, but significantly stimulated LTB4 both on days 1 and 7 after induction of colitis.
Neg (not) Positive_regulation (increase) of Localization (release) of PGE2 associated with colitis
11) Confidence 0.25 Published 1996 Journal Digestion Section Abstract Doc Link 8886582 Disease Relevance 0.78 Pain Relevance 0.26
We conclude that NE affected stimulated PGE2 release via alpha2-adrenoceptors on cells other than cutaneous afferents while kappa-opioid receptors are expressed in peripheral terminals of cutaneous afferents and their activation reduced CGRP release and secondary PGE2 formation.
Positive_regulation (stimulated) of Localization (release) of PGE2 in PGE2 associated with kappa opioid receptor and calcitonin gene-related peptide
12) Confidence 0.19 Published 2001 Journal Neuroreport Section Abstract Doc Link 11447314 Disease Relevance 0 Pain Relevance 0.56
Antidromic electrical nerve stimulation resulted in significant increases in the release of CGRP and PGE2.
Positive_regulation (increases) of Localization (release) of PGE2 in PGE2 associated with calcitonin gene-related peptide
13) Confidence 0.16 Published 2001 Journal Neuroreport Section Abstract Doc Link 11447314 Disease Relevance 0 Pain Relevance 0.56
The particle-induced release of PGE2 by AM affects neutrophil respiratory burst activity.
Positive_regulation (induced) of Localization (release) of PGE2 in respiratory
14) Confidence 0.14 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.38 Pain Relevance 0.19
In contrast, long-term exposure (3 h) induced a large amount of PGE2 release, which was completely abolished by indomethacin or NS-398.
Positive_regulation (induced) of Localization (release) of PGE2 in PGE2
15) Confidence 0.13 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16580130 Disease Relevance 0.39 Pain Relevance 0.75
increased PGE2 release in a time dependent manner and statistically significance reached from 4 h onward (Figure 7A).
Positive_regulation (increased) of Localization (release) of PGE2
16) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731738 Disease Relevance 0 Pain Relevance 0.20
-induced PGE2 release and mPGES-1 mRNA level by 10 ?
Positive_regulation (induced) of Localization (release) of PGE2
17) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.10
DETA/NO significantly increased PGE2 release after 6 and 8 h, while a significant inhibitory effect was observed at 12 h of incubation (Fig. 3B).
Positive_regulation (increased) of Localization (release) of PGE2
18) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731738 Disease Relevance 0.08 Pain Relevance 0.08
It has also been discovered that LPS stimulates the release of prostaglandin E2 from these cells.
Positive_regulation (stimulates) of Localization (release) of E2
19) Confidence 0.05 Published 2010 Journal Protoplasma Section Body Doc Link PMC2947012 Disease Relevance 0 Pain Relevance 0.15
Consistent with these data, we found that the stable and cell-permeable cGMP analog 8-Br-cGMP increased PGE2 release after 4-h and 8-h treatments, with significant effects observed at 100 ?
Positive_regulation (increased) of Localization (release) of PGE2
20) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731738 Disease Relevance 0.22 Pain Relevance 0.23

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