INT25958

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Context Info
Confidence 0.59
First Reported 1983
Last Reported 2011
Negated 7
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 11.88
Pain Relevance 7.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
brain 4
lung 2
plasma 1
striatum 1
kidney 1
Ace (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 35 100.00 Very High Very High Very High
Morphine 23 100.00 Very High Very High Very High
Enkephalin 16 99.84 Very High Very High Very High
Dynorphin 2 99.28 Very High Very High Very High
Endogenous opioid 10 99.20 Very High Very High Very High
substance P 9 98.84 Very High Very High Very High
bradykinin 17 98.00 Very High Very High Very High
Calcium channel 4 97.80 Very High Very High Very High
Neuropeptide 6 97.56 Very High Very High Very High
dexamethasone 2 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 16 100.00 Very High Very High Very High
Renal Disease 83 99.98 Very High Very High Very High
Diabetes Mellitus 147 99.90 Very High Very High Very High
Pre-eclampsia 46 99.84 Very High Very High Very High
Cancer 150 99.64 Very High Very High Very High
Shock 6 99.56 Very High Very High Very High
Coronary Artery Disease 94 99.40 Very High Very High Very High
Atherosclerosis 52 99.40 Very High Very High Very High
Hypertension 88 98.94 Very High Very High Very High
Schizophrenia 6 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in the levels of ACE have been found in brains of schizophrenia patients, suggesting an involvement of ACE in the illness which awaits further investigation.
Regulation (Changes) of ACE in brains associated with schizophrenia
1) Confidence 0.59 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15854741 Disease Relevance 0.31 Pain Relevance 0.39
A further "protective" role of ACE inhibitors in coronary artery disease is emerging as more attention is focused on the concept of local tissue renin-angiotensin systems.
Regulation (role) of ACE in coronary artery associated with coronary artery disease
2) Confidence 0.45 Published 1993 Journal Clin Cardiol Section Abstract Doc Link 8435934 Disease Relevance 0.46 Pain Relevance 0
In mouse models of diabetic nephropathy ACE-2 is down regulated [19] and knockout of ACE-2 or inhibition of its activity promotes proteinuria and worsens glomerular injury in this model [19, 20].
Regulation (regulated) of ACE associated with targeted disruption, injury, proteinuria and renal disease
3) Confidence 0.43 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.49 Pain Relevance 0
Based largely on preclinical data in chronic kidney disease models a number of clinical trials were conducted to assess the effects of ACE inhibitors and subsequently, ARBs, on the progression of diabetic and nondiabetic nephropathy.
Regulation (effects) of ACE in kidney associated with chronic renal failure, diabetes mellitus and renal disease
4) Confidence 0.43 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.84 Pain Relevance 0
Furthermore, in the brain regions studied, the corresponding enzyme activities of NEP and ACE did not differ significantly between the lines of mice, except for a higher NEP activity in the striatum and olfactory bulb of DBA/2 mice (p < 0.01).
Neg (except) Regulation (differ) of ACE in olfactory bulb
5) Confidence 0.42 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756041 Disease Relevance 0.32 Pain Relevance 0.35
Effects of the angiotensin-converting enzyme (ACE) inhibitors, imidapril and enalapril, on kaolin-induced writhing reaction, which is believed to be caused by bradykinin (BK), were examined in mice.
Spec (examined) Regulation (Effects) of ACE associated with bradykinin
6) Confidence 0.42 Published 2001 Journal Life Sci. Section Abstract Doc Link 11350012 Disease Relevance 0 Pain Relevance 0.16
Changes in the levels of angiotensin-converting enzyme (ACE) have been found in brains of schizophrenia patients, suggesting a possible involvement of angiotensin in the illness.
Regulation (Changes) of ACE in brains associated with schizophrenia
7) Confidence 0.41 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18037452 Disease Relevance 0.26 Pain Relevance 0.07
Another unique limitation to this study was the duration of therapy used, two years, as the full effect of ACE inhibitors has been hypothesized to take up to three years.
Regulation (effect) of ACE
8) Confidence 0.39 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.70 Pain Relevance 0
Another smaller study that failed to find significant effects of ACE inhibitors on atherosclerosis was the PART 2 trial.
Regulation (effects) of ACE associated with atherosclerosis
9) Confidence 0.39 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.67 Pain Relevance 0
Thus, as was seen in the PEACE trial, it seems plausible that lower levels of LDL from increased use of lipid lowering agents may negate the beneficial effect from ACE inhibitor treatment on atherosclerosis.
Regulation (effect) of ACE associated with atherosclerosis
10) Confidence 0.39 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.49 Pain Relevance 0.04
However, in contrast to ACD, the response to the irritant croton oil was not significantly altered in ACE(+/-) compared with ACE(+/+) mice.
Neg (not) Regulation (altered) of ACE associated with dermatitis
11) Confidence 0.27 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12646655 Disease Relevance 0.99 Pain Relevance 0.62
NAL which intensified the in vitro inhibitory effect of the used opioids showed an antagonistic effect on the in vivo suppressive effect of BETA-END on both brain and lung ACE activities whereas it had neither antagonistic nor synergistic effect on the in vivo inhibiting effect of MET-ENK and LEU-ENK on the lung ACE activity.
Neg (neither) Regulation (effect) of ACE in brain associated with narcan and opioid
12) Confidence 0.26 Published 1986 Journal Pharmacol Res Commun Section Abstract Doc Link 3014570 Disease Relevance 0 Pain Relevance 0.68
Angiotensin-converting enzyme (ACE) is crucial in the synthesis of angiotensin II, breakdown of bradykinin and the hydrolysis of several other neuropeptides such as enkephalin, substance P, dynorphin and neurotensin.
Regulation (crucial) of ACE associated with dynorphin, neuropeptide, enkephalin, bradykinin and substance p
13) Confidence 0.26 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15854741 Disease Relevance 0.20 Pain Relevance 0.29
In mouse models of diabetic nephropathy ACE-2 is down regulated [19] and knockout of ACE-2 or inhibition of its activity promotes proteinuria and worsens glomerular injury in this model [19, 20].
Regulation (regulated) of ACE associated with targeted disruption, injury, proteinuria and renal disease
14) Confidence 0.26 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.49 Pain Relevance 0
The effect of morphine, naloxone, D- and L-aspartic acid on the brain and lung ACE in mice.
Regulation (effect) of lung ACE in lung associated with narcan and morphine
15) Confidence 0.24 Published 1983 Journal Pharmacol Res Commun Section Title Doc Link 6101060 Disease Relevance 0 Pain Relevance 1.11
As a result the possible contributory action of the excessively released endogenous opioids to overcome shock via their inhibiting effect on ACE was discussed.
Regulation (effect) of ACE associated with shock and endogenous opioid
16) Confidence 0.23 Published 1986 Journal Pharmacol Res Commun Section Abstract Doc Link 3014570 Disease Relevance 0.10 Pain Relevance 0.63
This increase in ACE expression would need to be taken into consideration if targeting ACE in anti-cancer therapies.
Regulation (targeting) of ACE associated with cancer
17) Confidence 0.22 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.44 Pain Relevance 0
The high levels of tumor-derived ACE described here support reports of an up-regulation of ACE mRNA in primary CRCs compared to corresponding nonlesional tissues [39].
Regulation (regulation) of ACE mRNA associated with cancer
18) Confidence 0.22 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.60 Pain Relevance 0
ACE-inhibitor therapy had no effect on EET plasma levels (data not shown).
Neg (no) Regulation (effect) of ACE in plasma
19) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.16 Pain Relevance 0.03
Furthermore, in the brain regions studied, the corresponding enzyme activities of NEP and ACE did not differ significantly between the lines of mice, except for a higher NEP activity in the striatum and olfactory bulb of DBA/2 mice (p < 0.01).
Neg (except) Regulation (differ) of ACE in striatum
20) Confidence 0.14 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756041 Disease Relevance 0.32 Pain Relevance 0.35

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