INT25960

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Context Info
Confidence 0.32
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.69
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Dpp4) extracellular region (Dpp4) cell adhesion (Dpp4)
Golgi apparatus (Dpp4) endoplasmic reticulum (Dpp4) plasma membrane (Dpp4)
Anatomy Link Frequency
thymus 1
Dpp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 3 100.00 Very High Very High Very High
Inflammation 27 96.80 Very High Very High Very High
cINOD 2 95.48 Very High Very High Very High
dexamethasone 2 84.16 Quite High
Morphine 2 82.72 Quite High
Pain 1 68.96 Quite High
narcan 2 52.64 Quite High
Fibrositis 8 50.00 Quite Low
pressure hyperalgesia 2 50.00 Quite Low
Chronic pancreatitis 2 25.28 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 96.80 Very High Very High Very High
Hypertension 7 96.12 Very High Very High Very High
Diabetes Mellitus 83 95.28 Very High Very High Very High
Hyperlipidemia 10 92.84 High High
Body Weight 13 91.08 High High
Sprains And Strains 1 88.48 High High
Insulin Resistance 13 87.28 High High
Pain 1 68.96 Quite High
Stress 8 67.52 Quite High
Sleep Disorders 4 54.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Future studies from us will estimate the effects of this DPP-IV inhibitor on the enzyme activity/expression, as well as on levels of GLP-1 and glucagon, in order to have a more detailed picture of how the incretins pathway is affected and its relative contribution for the effects of sitagliptin here reported.
Regulation (effects) of DPP-IV
1) Confidence 0.32 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2905949 Disease Relevance 1.04 Pain Relevance 0
Dipeptidyl peptidase IV is a target for covalent adduct formation with the acyl glucuronide metabolite of the anti-inflammatory drug zomepirac.
Regulation (target) of peptidase IV associated with inflammation
2) Confidence 0.27 Published 2001 Journal Life Sci. Section Title Doc Link 11205870 Disease Relevance 0.19 Pain Relevance 0.14
The results verify that DPP IV is one of the protein targets for covalent modification during hepatic transport and biliary excretion of ZAG in rats.
Regulation (targets) of DPP IV
3) Confidence 0.27 Published 2001 Journal Life Sci. Section Abstract Doc Link 11205870 Disease Relevance 0.13 Pain Relevance 0.09
The aim of the work was to study the effect of glucocorticoids, opiates and stressful stimuli on dipeptidyl peptidase IV (DP IV, EC 3.4.14.5) activity of T lymphocytes prepared from the thymus of intact and adrenalectomized rats.
Regulation (effect) of peptidase IV in thymus associated with opiate
4) Confidence 0.19 Published 1989 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2544437 Disease Relevance 0.22 Pain Relevance 0.50
There were no significant effects of repeated administration of sertraline on serum PEP and DPP IV activity in patients with fibromyalgia.
Neg (no) Regulation (effects) of DPP IV
5) Confidence 0.13 Published 1998 Journal Psychol Med Section Body Doc Link 9723150 Disease Relevance 0.05 Pain Relevance 0
There were no significant changes in serum DPP IV activity in fibromyalgia.
Neg (no) Regulation (changes) of DPP IV
6) Confidence 0.13 Published 1998 Journal Psychol Med Section Body Doc Link 9723150 Disease Relevance 0.05 Pain Relevance 0

General Comments

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