INT259601

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.67
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp12) extracellular region (Mmp12) proteinaceous extracellular matrix (Mmp12)
Anatomy Link Frequency
macrophages 2
lung 2
sputum 1
Th1 cells 1
Mmp12 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 140 100.00 Very High Very High Very High
Inflammatory response 20 93.28 High High
Inflammation 394 91.64 High High
antagonist 64 90.00 High High
fibrosis 28 52.76 Quite High
chemokine 38 49.76 Quite Low
Inflammatory mediators 35 44.48 Quite Low
cytokine 46 5.00 Very Low Very Low Very Low
substance P 33 5.00 Very Low Very Low Very Low
Bioavailability 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 488 99.60 Very High Very High Very High
Sprains And Strains 63 99.34 Very High Very High Very High
Burns 3 98.48 Very High Very High Very High
Cancer 26 98.44 Very High Very High Very High
Emphysema 73 97.68 Very High Very High Very High
Pulmonary Emphysema 40 95.04 Very High Very High Very High
INFLAMMATION 363 92.92 High High
Disease 36 91.96 High High
Stress 24 82.08 Quite High
Leukocytosis 1 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cancer persisted at 16 weeks only in the A/J strain and contained a large number of upregulated genes such as C13ORF15, LRG1, LCN2, MMP12 and SAA2 (Table 4).
Positive_regulation (upregulated) of MMP12 associated with cancer and sprains and strains
1) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.50 Pain Relevance 0.12
Chronic CS-induced increase of MMP-12 in lung macrophages
Positive_regulation (increase) of MMP-12 in macrophages
2) Confidence 0.44 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.31 Pain Relevance 0.06
Interestingly, the MMP-12 induction upon CS-exposure was significantly attenuated in NK1-R-/- mice, compared to WT mice (Figure 5).


Positive_regulation (induction) of MMP-12
3) Confidence 0.34 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.37 Pain Relevance 0.15
This process may also contribute to COPD pathogenesis in human subjects, since lung tissue from human COPD patients contains increased numbers of Th1 cells associated with increased levels of IP-10 and MMP-12 (Grumelli et al 2004).
Positive_regulation (increased) of MMP-12 in Th1 cells associated with pulmonary disease
4) Confidence 0.31 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.62 Pain Relevance 0.17
Chronic CS-exposure revealed significantly increased MMP-12 staining in macrophages of WT mice, compared to air-exposed controls (Figure 5).
Positive_regulation (increased) of MMP-12 in macrophages
5) Confidence 0.29 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.37 Pain Relevance 0.13
Cigarette smoke acutely upregulates macrophage MMP-12 levels by injuring lung capillaries (Burns et al 1989; Li et al 1996), leading to leakage of thrombin and plasmin into the alveolar space.
Positive_regulation (upregulates) of MMP-12 in lung associated with burns
6) Confidence 0.27 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.75 Pain Relevance 0
Early studies failed to detect increased expression of MMP-12 in lung samples (Finlay et al 1997; Imai et al 2001), but more recent studies using other techniques have demonstrated increased levels of MMP-12 in human COPD (Grumelli et al 2004; Molet et al 2005; Woodruff et al 2005; Demedts et al 2006).
Positive_regulation (increased) of MMP-12 in lung associated with pulmonary disease
7) Confidence 0.27 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.96 Pain Relevance 0.11
Several studies reported enhanced levels or gene mutations of MMPs like MMP-1, MMP-9 or MMP-12 associated with COPD and lung function decline (Joos et al 2002; Culpitt et al 2005; Demedts et al 2006), the presence of fragments of ECM proteins like elastin or collagen (Dillon et al 1992; Stone et al 1995; Weathington et al 2006), and/or altered levels of ECM molecules in sputum, BAL fluid or lung tissue of patients with COPD (Lang et al 1994; Dentener et al 2005; Kranenburg et al 2006; Martin-Mosquero et al 2006).
Positive_regulation (enhanced) of MMP-12 in sputum associated with pulmonary disease and metalloproteinase
8) Confidence 0.08 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.78 Pain Relevance 0.29

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox