INT259604

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) cytoplasm (Elane)
Anatomy Link Frequency
plasma 2
lung 2
Elane (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 116 80.72 Quite High
metalloproteinase 76 72.84 Quite High
Inflammatory mediators 18 60.40 Quite High
fibrosis 18 9.64 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Emphysema 10 99.24 Very High Very High Very High
Pulmonary Disease 176 87.76 High High
INFLAMMATION 100 80.72 Quite High
Emphysema 14 38.96 Quite Low
Pathologic Processes 4 28.04 Quite Low
Apoptosis 28 21.76 Low Low
Adhesions 4 16.76 Low Low
Airway Obstruction 2 10.88 Low Low
Fibrosis 22 9.64 Low Low
Pneumonia 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While unrestrained NE activity in the lung is likely to be important in the panlobular pulmonary emphysema associated with ?
Positive_regulation (important) of NE Binding (activity) of in lung associated with pulmonary emphysema
1) Confidence 0.09 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.68 Pain Relevance 0.17
The inhibitor-resistance of membrane-bound NE is due to positive residues in NE binding to negatively charged sulfate groups in PMN plasma membrane proteoglycans (Campbell and Owen 2007), but the mechanism underlying the resistance of other cell-surface proteinases to inhibition is not known.
Positive_regulation (due) of NE Binding (binding) of in plasma
2) Confidence 0.08 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.13 Pain Relevance 0.07

General Comments

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