INT259610

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.22
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp12) extracellular region (Mmp12) proteinaceous extracellular matrix (Mmp12)
Anatomy Link Frequency
alveolar macrophages 4
macrophage 2
Mmp12 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 45 93.68 High High
Inflammation 151 91.68 High High
metalloproteinase 44 88.00 High High
substance P 33 87.36 High High
Inflammatory mediators 15 79.36 Quite High
Inflammatory response 10 44.44 Quite Low
chemokine 8 28.56 Quite Low
fibrosis 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
c fibre 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Emphysema 29 92.32 High High
Emphysema 37 91.88 High High
INFLAMMATION 131 91.68 High High
Fibrosis 11 85.76 High High
Pneumonia 40 80.80 Quite High
Apoptosis 17 76.80 Quite High
Death 8 64.96 Quite High
Targeted Disruption 12 64.20 Quite High
Nicotine Addiction 31 63.76 Quite High
Pulmonary Disease 166 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, immunohistochemical staining showed impaired production of MMP-12 in alveolar macrophages of CS-exposed NK1-R-/- mice.
Negative_regulation (impaired) of Gene_expression (production) of MMP-12 in alveolar macrophages
1) Confidence 0.37 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.52 Pain Relevance 0.15
Interestingly, the MMP-12 induction upon CS-exposure was significantly attenuated in NK1-R-/- mice, compared to WT mice (Figure 5).


Negative_regulation (attenuated) of Gene_expression (induction) of MMP-12
2) Confidence 0.31 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.43 Pain Relevance 0.16
Moreover, an impaired production of MMP-12 by alveolar macrophages upon CS-exposure was observed in these KO mice.
Negative_regulation (impaired) of Gene_expression (production) of MMP-12 in alveolar macrophages
3) Confidence 0.27 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2689186 Disease Relevance 0.99 Pain Relevance 0.25
However, plasmin also cleaves and activates latent growth factors, latent proMMPs, and protease-activated receptor-1 (PAR-1) on macrophages, which drives macrophage MMP-12 production (Saksela and Rifkin 1988; Taipale et al 1992; Raza et al 2000; Churg et al 2007b).
Negative_regulation (drives) of Gene_expression (production) of MMP-12 in macrophage
4) Confidence 0.25 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.28 Pain Relevance 0.10

General Comments

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