INT25962

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Context Info
Confidence 0.75
First Reported 1981
Last Reported 2010
Negated 8
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 20.04
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (COX8A) mitochondrion (COX8A) small molecule metabolic process (COX8A)
Anatomy Link Frequency
plasma 4
adrenal gland 2
spindle cells 1
Endothelial cells 1
muscle 1
COX8A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 97.76 Very High Very High Very High
cytokine 1 94.92 High High
cva 3 93.24 High High
Pain 9 90.92 High High
palliative 3 90.64 High High
Angina 2 89.92 High High
epidural 4 88.68 High High
analgesia 4 88.32 High High
shoulder pain 1 85.96 High High
Peripheral nervous system 3 84.96 Quite High
Disease Link Frequency Relevance Heat
Cancer 95 99.80 Very High Very High Very High
Malignant Neoplastic Disease 12 99.44 Very High Very High Very High
Hemangiosarcoma 23 98.60 Very High Very High Very High
Atherosclerosis 4 98.56 Very High Very High Very High
Glioma 3 98.44 Very High Very High Very High
Hemorrhage 3 98.12 Very High Very High Very High
Cyst 12 97.92 Very High Very High Very High
INFLAMMATION 12 97.76 Very High Very High Very High
Hyperplasia 1 97.76 Very High Very High Very High
Diabetes Mellitus 4 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cells were negative for desmin, factor VIII-related antigen, epithelial membrane antigen, cytokeratins, S-100 protein and chromogranin.
Neg (negative) Gene_expression (negative) of VIII
1) Confidence 0.75 Published 1993 Journal J. Cutan. Pathol. Section Abstract Doc Link 8227612 Disease Relevance 0.58 Pain Relevance 0.08
Tumor cells were also vasoformative and synthesized Factor VIII-related antigen.
Gene_expression (synthesized) of VIII associated with cancer
2) Confidence 0.75 Published 1984 Journal Hum. Pathol. Section Abstract Doc Link 6088383 Disease Relevance 1.30 Pain Relevance 0.08
Immunohistochemical staining demonstrated an intense expression of CD 31, CD 34, factor VIII related antigen and keratin.
Gene_expression (expression) of VIII
3) Confidence 0.75 Published 2000 Journal Virchows Arch. Section Abstract Doc Link 10963385 Disease Relevance 0.54 Pain Relevance 0.06
Expression and tissue distribution of COX isozymes were determined by northern and western blot analysis.
Gene_expression (Expression) of COX
4) Confidence 0.75 Published 2004 Journal Am. J. Vet. Res. Section Body Doc Link 15198222 Disease Relevance 0.08 Pain Relevance 0
The vascular endothelial cells (ECs) express various antigens related to coagulation factors, including factor VIII-related antigen or von Willebrand factor (vWF) in the cytoplasm and thrombomodulin (TM; a thrombin receptor)along the plasma membrane.
Gene_expression (express) of VIII in plasma
5) Confidence 0.75 Published 2005 Journal J Nippon Med Sch Section Abstract Doc Link 16415510 Disease Relevance 0 Pain Relevance 0.06
Endothelial cells were identified by their expression of an endothelial cell marker, Factor VIII/von Willebrand factor.
Gene_expression (expression) of VIII in Endothelial cells
6) Confidence 0.75 Published 1994 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 7820365 Disease Relevance 0.35 Pain Relevance 0.18
Factor VIII-related antigen was detected in 19 of 23 cases, BMA-120 in 18 of 23, UEA-1 receptor in 18 of 23, and vimentin in 23 of 23 as well as CD68 antigen in 1 of 23 cases.
Gene_expression (detected) of VIII
7) Confidence 0.75 Published 1993 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 8372948 Disease Relevance 1.07 Pain Relevance 0.06
Immunohistochemical staining was negative for the endothelial markers (CD31, CD34, and factor VIII-related antigen) and positive using cytokeratin antibodies (AE1/AE3 and 34 betaE12).
Neg (negative) Gene_expression (negative) of VIII
8) Confidence 0.65 Published 2005 Journal Am J Dermatopathol Section Abstract Doc Link 15798440 Disease Relevance 0.78 Pain Relevance 0.09
Tumor cells were positive for factor VIII-related antigen, MNF116, PAN-ceratin, CD 34, and CD 31 and negative for cytokeratin allowing the diagnosis of EHE.
Neg (negative) Gene_expression (positive) of VIII associated with cancer and epithelioid hemangioendothelioma
9) Confidence 0.65 Published 2005 Journal Thyroid Section Abstract Doc Link 16405412 Disease Relevance 1.22 Pain Relevance 0.09
Tumor cells were negative for desmin, factor VIII-related antigen, S-100 protein, neurofilament, cytokeratin, and epithelial membrane antigen.
Neg (negative) Gene_expression (negative) of VIII associated with cancer
10) Confidence 0.65 Published 1997 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9298887 Disease Relevance 1.07 Pain Relevance 0.07
The factor VIII-von Willebrand factor complex was documented in 84 patients, and plasma von Willebrand factor level was decreased (<60%) in 23 (27%) of them; 10 of the 84 patients (12%) had more notably decreased levels (<50%).
Gene_expression (documented) of VIII in plasma
11) Confidence 0.65 Published 2008 Journal Arch Dermatol Section Body Doc Link 18645137 Disease Relevance 0 Pain Relevance 0
The patients with IRS have higher values of fibrinogen, factor VII, VIII, Von Willebrand factor and Plasminogen Activator Inhibitor (PAI) compared to control subjects.
Gene_expression (values) of VIII
12) Confidence 0.65 Published 2009 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 19033264 Disease Relevance 2.68 Pain Relevance 0.49
All 42 cases studied immunohistochemically stained at least focally for Factor VIII-related antigen, and nearly all stained strongly for vimentin, which accentuated the endothelial cells and vessel lumen formation.
Gene_expression (stained) of VIII in lumen
13) Confidence 0.65 Published 1998 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9630175 Disease Relevance 1.36 Pain Relevance 0.15
Immunohistochemically, the tumor cells were positive for factor VIII-related antigen, CD31, and CD34, and negative for calretinin and WT-1.
Neg (negative) Gene_expression (positive) of VIII associated with cancer
14) Confidence 0.65 Published 2010 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 20560442 Disease Relevance 1.39 Pain Relevance 0.07
Numerous dilated, thin-walled, vascular channels that stained strongly for Factor VIII-related antigen, collagen IV, laminin, Ulex europaeus agglutinin I lectin, and CD34 were present within the fibrous capsule, cyst contents, and surrounding residual adrenal gland.
Gene_expression (stained) of VIII in adrenal gland associated with cyst
15) Confidence 0.65 Published 1997 Journal Mod. Pathol. Section Abstract Doc Link 9195568 Disease Relevance 0.54 Pain Relevance 0.05
Numerous dilated, thin-walled, vascular channels that stained strongly for Factor VIII-related antigen, collagen IV, laminin, Ulex europaeus agglutinin I lectin, and CD34 were present within the fibrous capsule, cyst contents, and surrounding residual adrenal gland.
Gene_expression (lectin) of VIII in adrenal gland associated with cyst
16) Confidence 0.65 Published 1997 Journal Mod. Pathol. Section Abstract Doc Link 9195568 Disease Relevance 0.56 Pain Relevance 0.06
They were uniformly negative for CAM5.2, epithelial membrane antigen, muscle-specific actin (HHF35), factor-VIII-related antigen, S-100 protein, neurofilament, CD34, and CD31.
Neg (negative) Gene_expression (negative) of VIII in muscle
17) Confidence 0.65 Published 1996 Journal Virchows Arch. Section Abstract Doc Link 8972766 Disease Relevance 0.93 Pain Relevance 0.08
Immunohistochemically, the spindle cells were focally positive for factor VIII-associated antigen and vimentin, and negative for S-100 protein, desmin, and epithelial membrane antigen.
Neg (negative) Gene_expression (positive) of VIII in spindle cells
18) Confidence 0.65 Published 1995 Journal J. Korean Med. Sci. Section Abstract Doc Link 8527049 Disease Relevance 0.67 Pain Relevance 0.15
Tumor cells were positive for factor VIII-related antigen and vimentin.
Gene_expression (positive) of VIII associated with cancer
19) Confidence 0.65 Published 1995 Journal South. Med. J. Section Abstract Doc Link 7631220 Disease Relevance 0.91 Pain Relevance 0.09
Postoperative changes in various haemostatic parameters (capillary bleeding time, platelet count, fibrinogen, fibrinmonomers, prothrombin, antithrombin III, factor VIII procoagulant, factor VIII antigen, euglobulin clot lysis time, streptokinase lysis time, fibrinogen related antigens, alpha 1-antitrypsin and alpha 2-macroglobulin) plasma glucose and cortisol were studied in 12 female patients undergoing elective abdominal hysterectomy during either general anaesthesia or epidural analgesia (T4-S5).
Gene_expression (procoagulant) of VIII in plasma associated with epidural, hemorrhage and analgesia
20) Confidence 0.65 Published 1981 Journal Br J Surg Section Abstract Doc Link 7225737 Disease Relevance 0.15 Pain Relevance 0.45

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