INT259622

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ecm1) extracellular space (Ecm1) peptidase activity (Elane)
extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1) enzyme binding (Ecm1)
Elane (Mus musculus)
Ecm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 58 94.80 High High
metalloproteinase 38 5.00 Very Low Very Low Very Low
Inflammatory mediators 9 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pneumonia 19 95.20 Very High Very High Very High
Pulmonary Disease 88 69.76 Quite High
INFLAMMATION 50 58.64 Quite High
Lung Injury 6 51.68 Quite High
Necrosis 3 51.36 Quite High
Hemophilus Infection 1 42.36 Quite Low
Apoptosis 14 38.32 Quite Low
Fibrosis 11 5.00 Very Low Very Low Very Low
Emphysema 7 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantum bursts of NE-mediated proteolytic activity associated with PMN migrating on ECM proteins are 10-fold larger in area and 4-fold longer in duration when PMN are bathed in serum from PiZZ patients compared to serum from healthy PiMM subjects (Campbell et al 1999), due to defective confinement of PMN-derived NE-mediated ECM degradation.
NE Positive_regulation (mediated) of Protein_catabolism (degradation) of ECM
1) Confidence 0.00 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.38 Pain Relevance 0.08

General Comments

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