INT259623

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.38
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) mitochondrion (Eln) extracellular region (Eln)
proteinaceous extracellular matrix (Eln) extracellular matrix organization (Eln) cytoplasm (Elane)
Anatomy Link Frequency
lung 2
Eln (Mus musculus)
Elane (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 18 84.80 Quite High
metalloproteinase 76 83.76 Quite High
Inflammation 116 78.52 Quite High
Inflammatory mediators 18 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Emphysema 10 96.84 Very High Very High Very High
Emphysema 14 92.56 High High
Pulmonary Disease 176 88.44 High High
Fibrosis 22 84.80 Quite High
INFLAMMATION 100 78.52 Quite High
Adhesions 4 77.88 Quite High
Nicotine Addiction 8 77.52 Quite High
Injury 6 65.32 Quite High
Infection 2 63.48 Quite High
Pneumonia 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since NE is bound to interstitial elastin in human emphysematous lungs (Damiano et al 1986), lung elastin-bound NE likely retains catalytic activity and contributes critically to destruction of elastin fibers in pulmonary emphysema (Figure 4).
elastin Binding (bound) of NE in lung associated with pulmonary emphysema
1) Confidence 0.02 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.30 Pain Relevance 0.08
They localized NE bound to lung elastic fibers and showed that the amount of NE bound to lung elastin is strongly correlated with the degree of emphysematous change.
elastin Binding (bound) of NE in lung
2) Confidence 0.01 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.08 Pain Relevance 0.15

General Comments

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