INT25963

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Context Info
Confidence 0.75
First Reported 1989
Last Reported 2010
Negated 46
Speculated 2
Reported most in Abstract
Documents 122
Total Number 126
Disease Relevance 98.81
Pain Relevance 11.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DES) cytoskeleton (DES) intracellular (DES)
cytoskeleton organization (DES) cytoplasm (DES)
Anatomy Link Frequency
smooth muscle 27
muscle 7
filament 6
neuron 5
spindle cells 3
DES (Homo sapiens)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 1 100.00 Very High Very High Very High
Enkephalin 2 99.28 Very High Very High Very High
substance P 1 98.96 Very High Very High Very High
B1 receptor 21 98.44 Very High Very High Very High
palliative 12 98.16 Very High Very High Very High
agonist 6 97.96 Very High Very High Very High
Dismenorea 22 97.04 Very High Very High Very High
adenocard 62 95.44 Very High Very High Very High
abdominal pain 46 95.04 Very High Very High Very High
Inflammation 161 94.08 High High
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 5 100.00 Very High Very High Very High
Cancer 1920 99.90 Very High Very High Very High
Muscle Disease 257 99.88 Very High Very High Very High
Clear Cell Sarcoma 36 99.84 Very High Very High Very High
Uterine Fibroids 32 99.68 Very High Very High Very High
Necrosis 55 99.46 Very High Very High Very High
Malignant Neoplastic Disease 230 99.40 Very High Very High Very High
Carcinoma 184 99.34 Very High Very High Very High
Leiomyosarcoma 47 99.08 Very High Very High Very High
Synovial Sarcoma 35 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Desmin, actin, Myf4, and MyoD1 were positive in tumor cells, and a diagnosis of rhabdomyosarcoma was eventually made.
Gene_expression (positive) of Desmin associated with cancer and rhabdomyosarcoma
1) Confidence 0.75 Published 2007 Journal Pathol. Res. Pract. Section Abstract Doc Link 17905523 Disease Relevance 1.50 Pain Relevance 0.07
The immunohistochemical study showed that tumor cells were positive for S-100 protein and CD57, and the rhabdomyoblasts expressed desmin, Myo-D1, and myoglobin.
Gene_expression (expressed) of desmin associated with cancer
2) Confidence 0.75 Published 2003 Journal Pediatr. Dev. Pathol. Section Abstract Doc Link 12545406 Disease Relevance 1.06 Pain Relevance 0.13
There was a positive correlation between alpha-smooth muscle antibody, desmin, and synaptophysin expression and the degree of fibrosis.
Gene_expression (expression) of desmin in smooth muscle
3) Confidence 0.75 Published 2003 Journal Pancreas Section Body Doc Link 12657949 Disease Relevance 0 Pain Relevance 0
Desmin and caldesmon were negative in all of these cases.
Neg (negative) Gene_expression (negative) of Desmin
4) Confidence 0.75 Published 2003 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 12766582 Disease Relevance 1.36 Pain Relevance 0.59
Among non-epithelial cells, stellate cells express variable amounts of GFAP, desmin, vimentin, and nestin dependent on their activation status, localization, and other parameters (TableĀ 3; Geerts 2001).
Gene_expression (express) of desmin in epithelial cells
5) Confidence 0.75 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.43 Pain Relevance 0.04
The expressions of OTR, CD10, h-caldesmon, calponin, smooth muscle actin, and desmin were analyzed in 10 conventional leiomyomas (LMs), 10 highly cellular leiomyomas (HCLs), eight leiomyosarcomas (LMSs), and nine ESSs.
Spec (analyzed) Gene_expression (expressions) of desmin in smooth muscle associated with endometrial stromal sarcoma, leiomyosarcoma and uterine fibroids
6) Confidence 0.75 Published 2003 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 14576480 Disease Relevance 1.54 Pain Relevance 0.09
The tumors ranged in size from 2.1 to 32 cm with a median size of 12 cm and expressed CD117 (c-kit receptor) (100%), CD34 (50%), neuron-specific enolase (44%), SMA (26%), desmin (4%), and S-100 protein (4%).
Gene_expression (expressed) of desmin in neuron associated with cancer
7) Confidence 0.75 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2267191 Disease Relevance 0.49 Pain Relevance 0
Immunohistochemical studies revealed diffuse positivity for desmin and poor expression for other smooth muscle and skeletal muscle markers (muscle-specific actin [0/3], alpha-smooth muscle actin 1/3 [focal], calponin [1/3], caldesmon [0/3], and myogenin [0/3]).
Gene_expression (expression) of desmin in skeletal muscle
8) Confidence 0.75 Published 2005 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 15864383 Disease Relevance 1.30 Pain Relevance 0.33
Immunohistochemical studies showed weak membranous positivity for epithelial membrane antigen and focal cytoplasmic positivity for CD34; stains for smooth muscle actin, cytokeratin AE1/AE3, desmin, CD56, H-caldesmon, calponin, and S-100 protein were negative.
Neg (negative) Gene_expression (negative) of desmin in smooth muscle
9) Confidence 0.75 Published 2005 Journal Ann Diagn Pathol Section Abstract Doc Link 16084452 Disease Relevance 0.96 Pain Relevance 0.10
Desmin was expressed in fewer than 5% of the stromal cells.
Gene_expression (expressed) of Desmin in stromal cells
10) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1420311 Disease Relevance 0.63 Pain Relevance 0.04
Immunohistochemically, the neoplastic cells were positive for vimentin, smooth muscle actin, desmin and calponin, negative for S-100 protein, CD34, CD31 and cytokeratins (AE1/AE3, Cam 5.2).
Neg (negative) Gene_expression (negative) of desmin in smooth muscle
11) Confidence 0.75 Published 2005 Journal Pathologica Section Abstract Doc Link 16619980 Disease Relevance 0.15 Pain Relevance 0.08
Neoplastic cells were strongly immunoreactive for CD99 and vimentin and were negative for chromogranin, synaptophysin, CD31, CD34, calcitonin, desmin, low-molecular weight cytokeratins, wide-spectrum cytokeratins, leukocyte common antigen, S-100 protein, and thyroid transcription factor-1.
Neg (negative) Gene_expression (negative) of desmin in thyroid
12) Confidence 0.75 Published 2008 Journal Tumori Section Abstract Doc Link 19267114 Disease Relevance 1.38 Pain Relevance 0.16
Immunohistochemical staining revealed diffuse expression of neurofilament protein and focal expression of desmin and myoglobin.
Gene_expression (expression) of desmin
13) Confidence 0.75 Published 2008 Journal Brain Tumor Pathol Section Abstract Doc Link 18415665 Disease Relevance 0.55 Pain Relevance 0.12
All were negative for leukocyte common antigen, Tdt, CD3, CD20, CD79, CK20, pankeratin, epithelial membrane antigen, chromogranin, neurofilament protein, carcinoembryonic antigen, desmin, actin, diffuse S100 protein, and HMB45.
Neg (negative) Gene_expression (negative) of desmin in leukocyte
14) Confidence 0.75 Published 2007 Journal Ann Diagn Pathol Section Abstract Doc Link 17498589 Disease Relevance 0.76 Pain Relevance 0.07
Immunohistochemical staining revealed diffuse expression of neurofilament protein, desmin, and myoglobin.
Gene_expression (expression) of desmin
15) Confidence 0.75 Published 2008 Journal Brain Tumor Pathol Section Abstract Doc Link 18415665 Disease Relevance 0.69 Pain Relevance 0.11
Immunohistochemical staining revealed diffuse expression of synaptophysin and neurofilament protein, and focal expression of glial fibrillary acidic protein, S-100 protein, desmin, and myoglobin.
Gene_expression (expression) of desmin
16) Confidence 0.75 Published 2008 Journal Brain Tumor Pathol Section Abstract Doc Link 18415665 Disease Relevance 0.71 Pain Relevance 0.09
Immunohistochemical analysis was positive for vimentin and weakly positive for CD34, while CD117, S-100, smooth muscle actin, desmin, and CD68 were negative.
Neg (negative) Gene_expression (negative) of desmin in smooth muscle
17) Confidence 0.75 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2443155 Disease Relevance 0.65 Pain Relevance 0.12
The neoplastic cells were positive for vimentin, alpha smooth muscle actin, osteonectin, CD99, and S100 in the chondroblastic portion, but negative for cytokeratin, epithelial membrane antigen, desmin, myogenin, CD34, and c-kit.
Neg (negative) Gene_expression (negative) of desmin in smooth muscle
18) Confidence 0.75 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1878495 Disease Relevance 0.69 Pain Relevance 0.04
Immunohistochemically co-expression of cytokeratin, vimentin, desmin, and NSE was observed.
Gene_expression (co-expression) of desmin
19) Confidence 0.75 Published 2002 Journal Lung Cancer Section Abstract Doc Link 12009247 Disease Relevance 0.54 Pain Relevance 0.14
The spindle cells of sarcomatoid carcinomas often label for actin, although desmin is not frequently expressed.
Neg (not) Gene_expression (expressed) of desmin in spindle cells associated with carcinoma
20) Confidence 0.75 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC3016302 Disease Relevance 1.19 Pain Relevance 0

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