INT259637

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.71
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp12) extracellular region (Mmp12) proteinaceous extracellular matrix (Mmp12)
Anatomy Link Frequency
sputum 1
Mmp12 (Mus musculus)
COPD (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 57 100.00 Very High Very High Very High
Inflammation 158 72.68 Quite High
chemokine 22 42.40 Quite Low
cytokine 31 5.00 Very Low Very Low Very Low
antagonist 19 5.00 Very Low Very Low Very Low
Bioavailability 11 5.00 Very Low Very Low Very Low
Inflammatory mediators 11 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 232 100.00 Very High Very High Very High
Emphysema 29 95.16 Very High Very High Very High
Disease 15 84.60 Quite High
Stress 23 79.56 Quite High
INFLAMMATION 156 72.68 Quite High
Lung Injury 8 63.16 Quite High
Pneumonia 23 61.68 Quite High
Cancer 7 55.60 Quite High
Lower Respiratory Tract Infection 1 36.40 Quite Low
Lung Cancer 1 33.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, PMN-derived serine proteinases and MMPs in addition to MMP-12 may be important in human COPD.
MMP-12 Binding (important) of COPD associated with pulmonary disease and metalloproteinase
1) Confidence 0.02 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.93 Pain Relevance 0.11
Several studies reported enhanced levels or gene mutations of MMPs like MMP-1, MMP-9 or MMP-12 associated with COPD and lung function decline (Joos et al 2002; Culpitt et al 2005; Demedts et al 2006), the presence of fragments of ECM proteins like elastin or collagen (Dillon et al 1992; Stone et al 1995; Weathington et al 2006), and/or altered levels of ECM molecules in sputum, BAL fluid or lung tissue of patients with COPD (Lang et al 1994; Dentener et al 2005; Kranenburg et al 2006; Martin-Mosquero et al 2006).
MMP-12 Binding (associated) of COPD in sputum associated with pulmonary disease and metalloproteinase
2) Confidence 0.01 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.78 Pain Relevance 0.29

General Comments

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