INT259638

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.31
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFE2L2) plasma membrane (NFE2L2) nucleus (NFE2L2)
DNA binding (NFE2L2) cytoplasm (NFE2L2)
COPD (Homo sapiens)
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 31 93.08 High High
antagonist 4 42.84 Quite Low
fibrosis 3 29.24 Quite Low
cytokine 14 23.56 Low Low
metalloproteinase 11 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 99 100.00 Very High Very High Very High
Nicotine Addiction 48 100.00 Very High Very High Very High
Asthma 2 93.52 High High
INFLAMMATION 40 93.08 High High
Emphysema 31 90.88 High High
Stress 15 72.68 Quite High
Injury 2 60.16 Quite High
Disease 17 59.28 Quite High
Respiratory Syncytial Virus 1 31.76 Quite Low
Fibrosis 3 29.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of transcription factor binding sites occurring in the promoter regions of differentially expressed genes revealed that Nrf2 sties were overrepresented among those genes that were both upregulated by smoking (relative to nonsmokers) and upregulated by COPD (relative to healthy smokers) (Pierrou et al 2007).
COPD Positive_regulation (upregulated) of Nrf2 associated with pulmonary disease and nicotine addiction
1) Confidence 0.03 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 1.31 Pain Relevance 0.05

General Comments

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