INT259745

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.00
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSK3A) carbohydrate metabolic process (GSK3A)
GSK3A (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 54.12 Quite High
Ziconotide 3 43.04 Quite Low
Lasting pain 3 36.56 Quite Low
Inflammation 3 36.00 Quite Low
antagonist 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 176 99.64 Very High Very High Very High
Cancer 122 98.78 Very High Very High Very High
Disease 36 98.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 93.16 High High
Death 30 90.24 High High
Apoptosis 16 88.56 High High
Neuroblastoma 11 71.52 Quite High
Toxicity 2 52.20 Quite High
Disease Progression 2 51.52 Quite High
Breast Cancer 28 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we have shown that Raf-1 activation in human MTC cells results in phosphorylation and subsequent inactivation of GSK-3ß [30]; likewise, inactivation of GSK-3ß by phosphorylation results in MTC growth inhibition both in vitro and in vivo.
Phosphorylation (phosphorylation) of GSK-3 associated with thyroid neoplasm
1) Confidence 0.20 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.71 Pain Relevance 0
Recently, we have shown that Raf-1 activation in human MTC cells results in phosphorylation and subsequent inactivation of GSK-3ß [30]; likewise, inactivation of GSK-3ß by phosphorylation results in MTC growth inhibition both in vitro and in vivo.
Phosphorylation (phosphorylation) of GSK-3 associated with thyroid neoplasm
2) Confidence 0.20 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.76 Pain Relevance 0
We here report that lamellarins inhibit several protein kinases relevant to cancer such as cyclin-dependent kinases, dual-specificity tyrosine phosphorylation activated kinase 1A, casein kinase 1, glycogen synthase kinase-3 and PIM-1.
Phosphorylation (phosphorylation) of glycogen synthase kinase-3 associated with cancer
3) Confidence 0.11 Published 2008 Journal Mar Drugs Section Abstract Doc Link PMC2630805 Disease Relevance 0.45 Pain Relevance 0
In the course of screening for pharmacological inhibitors of disease-relevant protein kinases such as cyclin-dependent kinases (CDKs) [28, 29], glycogen synthase kinase-3 (GSK-3) [30], PIM1 [31], “dual-specificity, tyrosine phosphorylation regulated kinase 1A” (DYRK1A) [32–34], casein kinase 1 (CK1) [35], we discovered that several lamellarins inhibit the catalytic activity of some of these kinases.
Phosphorylation (phosphorylation) of GSK-3 associated with disease
4) Confidence 0.11 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630805 Disease Relevance 0.54 Pain Relevance 0.05
In the course of screening for pharmacological inhibitors of disease-relevant protein kinases such as cyclin-dependent kinases (CDKs) [28, 29], glycogen synthase kinase-3 (GSK-3) [30], PIM1 [31], “dual-specificity, tyrosine phosphorylation regulated kinase 1A” (DYRK1A) [32–34], casein kinase 1 (CK1) [35], we discovered that several lamellarins inhibit the catalytic activity of some of these kinases.
Phosphorylation (phosphorylation) of glycogen synthase kinase-3 associated with disease
5) Confidence 0.11 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630805 Disease Relevance 0.54 Pain Relevance 0.05
In the absence of Wnt ligands, a complex containing APC, AXIN and GSK3 phosphorylates ?
Phosphorylation (phosphorylates) of GSK3
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0 Pain Relevance 0

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