INT259745

Context Info Confidence 0.20 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 3.00 Pain Relevance 0.11

cytosol (GSK3A) carbohydrate metabolic process (GSK3A)

GSK3A (Homo sapiens)

Pain Link Frequency Relevance Heat tetrodotoxin 3 54.12 Ziconotide 3 43.04 Lasting pain 3 36.56 Inflammation 3 36.00 antagonist 4 5.00 Central nervous system 3 5.00 palliative 2 5.00 cINOD 2 5.00 addiction 2 5.00 Somatostatin 2 5.00

Disease Link Frequency Relevance Heat Thyroid Neoplasm 176 99.64 Cancer 122 98.78 Disease 36 98.48 Acquired Immune Deficiency Syndrome Or Hiv Infection 3 93.16 Death 30 90.24 Apoptosis 16 88.56 Neuroblastoma 11 71.52 Toxicity 2 52.20 Disease Progression 2 51.52 Breast Cancer 28 50.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently, we have shown that Raf-1 activation in human MTC cells results in phosphorylation and subsequent inactivation of GSK-3ß [30]; likewise, inactivation of GSK-3ß by phosphorylation results in MTC growth inhibition both in vitro and in vivo.

Phosphorylation (phosphorylation) of GSK-3 associated with thyroid neoplasm

1) Confidence 0.20 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.71 Pain Relevance 0

Recently, we have shown that Raf-1 activation in human MTC cells results in phosphorylation and subsequent inactivation of GSK-3ß [30]; likewise, inactivation of GSK-3ß by phosphorylation results in MTC growth inhibition both in vitro and in vivo.

Phosphorylation (phosphorylation) of GSK-3 associated with thyroid neoplasm

2) Confidence 0.20 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.76 Pain Relevance 0

We here report that lamellarins inhibit several protein kinases relevant to cancer such as cyclin-dependent kinases, dual-specificity tyrosine phosphorylation activated kinase 1A, casein kinase 1, glycogen synthase kinase-3 and PIM-1.

Phosphorylation (phosphorylation) of glycogen synthase kinase-3 associated with cancer

3) Confidence 0.11 Published 2008 Journal Mar Drugs Section Abstract Doc Link PMC2630805 Disease Relevance 0.45 Pain Relevance 0

In the course of screening for pharmacological inhibitors of disease-relevant protein kinases such as cyclin-dependent kinases (CDKs) [28, 29], glycogen synthase kinase-3 (GSK-3) [30], PIM1 [31], “dual-specificity, tyrosine phosphorylation regulated kinase 1A” (DYRK1A) [32–34], casein kinase 1 (CK1) [35], we discovered that several lamellarins inhibit the catalytic activity of some of these kinases.

Phosphorylation (phosphorylation) of GSK-3 associated with disease

4) Confidence 0.11 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630805 Disease Relevance 0.54 Pain Relevance 0.05

In the course of screening for pharmacological inhibitors of disease-relevant protein kinases such as cyclin-dependent kinases (CDKs) [28, 29], glycogen synthase kinase-3 (GSK-3) [30], PIM1 [31], “dual-specificity, tyrosine phosphorylation regulated kinase 1A” (DYRK1A) [32–34], casein kinase 1 (CK1) [35], we discovered that several lamellarins inhibit the catalytic activity of some of these kinases.

Phosphorylation (phosphorylation) of glycogen synthase kinase-3 associated with disease

5) Confidence 0.11 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630805 Disease Relevance 0.54 Pain Relevance 0.05

In the absence of Wnt ligands, a complex containing APC, AXIN and GSK3 phosphorylates ?

Phosphorylation (phosphorylates) of GSK3

6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0 Pain Relevance 0

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