INT259745
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Recently, we have shown that Raf-1 activation in human MTC cells results in phosphorylation and subsequent inactivation of GSK-3ß [30]; likewise, inactivation of GSK-3ß by phosphorylation results in MTC growth inhibition both in vitro and in vivo. | |||||||||||||||
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Recently, we have shown that Raf-1 activation in human MTC cells results in phosphorylation and subsequent inactivation of GSK-3ß [30]; likewise, inactivation of GSK-3ß by phosphorylation results in MTC growth inhibition both in vitro and in vivo. | |||||||||||||||
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We here report that lamellarins inhibit several protein kinases relevant to cancer such as cyclin-dependent kinases, dual-specificity tyrosine phosphorylation activated kinase 1A, casein kinase 1, glycogen synthase kinase-3 and PIM-1. | |||||||||||||||
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In the course of screening for pharmacological inhibitors of disease-relevant protein kinases such as cyclin-dependent kinases (CDKs) [28, 29], glycogen synthase kinase-3 (GSK-3) [30], PIM1 [31], dual-specificity, tyrosine phosphorylation regulated kinase 1A (DYRK1A) [3234], casein kinase 1 (CK1) [35], we discovered that several lamellarins inhibit the catalytic activity of some of these kinases. | |||||||||||||||
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In the course of screening for pharmacological inhibitors of disease-relevant protein kinases such as cyclin-dependent kinases (CDKs) [28, 29], glycogen synthase kinase-3 (GSK-3) [30], PIM1 [31], dual-specificity, tyrosine phosphorylation regulated kinase 1A (DYRK1A) [3234], casein kinase 1 (CK1) [35], we discovered that several lamellarins inhibit the catalytic activity of some of these kinases. | |||||||||||||||
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In the absence of Wnt ligands, a complex containing APC, AXIN and GSK3 phosphorylates ? | |||||||||||||||
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General Comments
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