INT259746

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.99
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CSNK1D) signal transduction (CSNK1D) Golgi apparatus (CSNK1D)
plasma membrane (CSNK1D) cytoskeleton (CSNK1D) nucleus (CSNK1D)
CSNK1D (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 50.92 Quite High
Ziconotide 2 39.84 Quite Low
Lasting pain 2 33.36 Quite Low
Inflammation 2 32.80 Quite Low
Central nervous system 2 8.32 Low Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 22 98.78 Very High Very High Very High
Disease 12 96.88 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 89.96 High High
Death 20 89.00 High High
Apoptosis 6 88.56 High High
Neuroblastoma 6 75.92 Quite High
Neurodegenerative Disease 4 43.44 Quite Low
Pain 2 33.36 Quite Low
INFLAMMATION 2 32.80 Quite Low
Prostate Cancer 2 18.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We here report that lamellarins inhibit several protein kinases relevant to cancer such as cyclin-dependent kinases, dual-specificity tyrosine phosphorylation activated kinase 1A, casein kinase 1, glycogen synthase kinase-3 and PIM-1.
Phosphorylation (phosphorylation) of casein kinase 1 associated with cancer
1) Confidence 0.03 Published 2008 Journal Mar Drugs Section Abstract Doc Link PMC2630805 Disease Relevance 0.45 Pain Relevance 0
In the course of screening for pharmacological inhibitors of disease-relevant protein kinases such as cyclin-dependent kinases (CDKs) [28, 29], glycogen synthase kinase-3 (GSK-3) [30], PIM1 [31], “dual-specificity, tyrosine phosphorylation regulated kinase 1A” (DYRK1A) [32–34], casein kinase 1 (CK1) [35], we discovered that several lamellarins inhibit the catalytic activity of some of these kinases.
Phosphorylation (phosphorylation) of casein kinase 1 associated with disease
2) Confidence 0.03 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630805 Disease Relevance 0.54 Pain Relevance 0.05

General Comments

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