INT259760

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.55
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fbn2) proteinaceous extracellular matrix (Fbn2)
Anatomy Link Frequency
primary sensory neurons 1
Fbn2 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 320 100.00 Very High Very High Very High
Sciatic nerve 115 99.92 Very High Very High Very High
Eae 34 99.90 Very High Very High Very High
Peripheral nerve injury 14 99.36 Very High Very High Very High
Hyperalgesia 4 98.16 Very High Very High Very High
Spontaneous pain 4 92.92 High High
hyperexcitability 31 90.56 High High
c fibre 9 87.60 High High
withdrawal 32 86.04 High High
adenocard 88 80.84 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 324 100.00 Very High Very High Very High
Nerve Compression Syndromes 211 100.00 Very High Very High Very High
Neuropathic Pain 93 100.00 Very High Very High Very High
Injury 68 99.90 Very High Very High Very High
Nervous System Injury 25 99.36 Very High Very High Very High
Hyperalgesia 4 98.16 Very High Very High Very High
Nociception 32 97.64 Very High Very High Very High
Wallerian Degeneration 1 95.32 Very High Very High Very High
Pain 34 92.92 High High
INFLAMMATION 10 55.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, CCI and SNE cause selective degeneration of A?
Localization (cause) of SNE associated with eae and nerve compression syndromes
1) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 1.28 Pain Relevance 0.94
In support of our hypothesis, we observed a robust KCl-evoked release of ATP in DRG ipsilateral to SNE during A1R blockade (Fig. 4D and 4E).


Localization (release) of SNE associated with dorsal root ganglion and nerve compression syndromes
2) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 1.74 Pain Relevance 0.61
Basal ATP release from L4/L5 DRG after SNE
Localization (release) of SNE associated with dorsal root ganglion and nerve compression syndromes
3) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 0.94 Pain Relevance 0.46
Thus, SNE neuropathy-induced increases in ATP metabolism and release may contribute to enhanced generation and transmission of nociceptive signals at peripheral terminals, along the axons, within the DRG and at central terminals of primary sensory neurons.
Localization (release) of SNE in primary sensory neurons associated with nociception, dorsal root ganglion, neuropathic pain and nerve compression syndromes
4) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 1.21 Pain Relevance 0.58
In addition to increased basal ATP levels, we no longer observed a KCl-evoked release of ATP after SNE.
Localization (release) of SNE associated with nerve compression syndromes
5) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 0.38 Pain Relevance 0.25

General Comments

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