INT25981

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Context Info
Confidence 0.26
First Reported 1985
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.07
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RTCA) RNA binding (RTCA) nucleus (RTCA)
ligase activity (RTCA)
Anatomy Link Frequency
parietal cells 1
platelet 1
fat cells 1
SK-N-SH 1
RTCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 3 99.96 Very High Very High Very High
cINOD 18 99.06 Very High Very High Very High
Morphine 6 91.76 High High
agonist 31 89.00 High High
addiction 3 75.00 Quite High
Clonidine 2 74.12 Quite High
adenocard 2 70.68 Quite High
antagonist 8 61.08 Quite High
narcan 1 49.68 Quite Low
withdrawal 8 47.04 Quite Low
Disease Link Frequency Relevance Heat
Obesity 3 98.80 Very High Very High Very High
Rheumatoid Arthritis 5 98.40 Very High Very High Very High
Neuroblastoma 6 97.30 Very High Very High Very High
INFLAMMATION 7 96.74 Very High Very High Very High
Vibrio Infection 3 96.64 Very High Very High Very High
Colon Cancer 64 92.08 High High
Bordatella Infection 6 87.40 High High
Morphine Dependence 1 75.00 Quite High
Arthritis 3 69.36 Quite High
Osteoarthritis 1 66.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alpha 2-adrenergic receptor-mediated regulation of adenylate cyclase in the intact human platelet.
Regulation (regulation) of cyclase in platelet
1) Confidence 0.26 Published 1985 Journal Mol. Pharmacol. Section Title Doc Link 2981397 Disease Relevance 0 Pain Relevance 0.22
No changes were found on the level of adenylate cyclase.
Neg (No) Regulation (changes) of cyclase
2) Confidence 0.10 Published 1996 Journal Brain Res. Section Abstract Doc Link 8919301 Disease Relevance 0.25 Pain Relevance 0.49
Although a principal pharmacological action of nonsteroidal anti-inflammatory drugs (NSAIDs) is to blunt eicosanoid synthesis by inhibiting cyclooxygenase, recent evidence indicates that NSAIDs may also interact directly with proteins that control the activity of adenylyl cyclase.
Regulation (control) of cyclase associated with inflammation and cinod
3) Confidence 0.08 Published 1994 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 8039282 Disease Relevance 0.38 Pain Relevance 0.51
Antilipolytic effects of insulin and adenylate cyclase inhibitors on isolated human fat cells.
Regulation (effects) of cyclase in fat cells associated with obesity
4) Confidence 0.08 Published 1989 Journal Int J Obes Section Title Doc Link 2545639 Disease Relevance 0.56 Pain Relevance 0.23
In the human NB line, SH-SY5Y (a neuroblastic subclone of SK-N-SH), RA was previously shown to enhance the stimulatory (PGE1) and inhibitory (opioid) regulation of adenylyl cyclase.
Regulation (regulation) of cyclase in SK-N-SH associated with neuroblastoma, rheumatoid arthritis and opioid
5) Confidence 0.05 Published 1989 Journal FEBS Lett. Section Abstract Doc Link 2546814 Disease Relevance 0.72 Pain Relevance 0.10
Since it is known that guanylate cyclase is a general target of NO in many cell systems, some investigators have suggested that NO exerts its effects via cyclic guanosine 3',5'-monophosphate (cGMP) in both rat and rabbit parietal cells [13,15].
Regulation (target) of cyclase in parietal cells
6) Confidence 0.01 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC514546 Disease Relevance 0 Pain Relevance 0
The major intracellular effect of Gi-protein signalling is a down regulation of cAMP levels via the inhibition of adenylate cyclase, suggesting that inhibition of cAMP signalling is an important component of the proliferative signal elicited by low PGE2 doses.
Regulation (regulation) of cyclase
7) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.17 Pain Relevance 0.08

General Comments

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