INT259833

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.47
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr12) intracellular (Tlr12)
Anatomy Link Frequency
brain 3
pyramidal neurons 1
neurons 1
Tlr12 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 160 98.24 Very High Very High Very High
Pyramidal cell 10 97.04 Very High Very High Very High
Hippocampus 10 96.04 Very High Very High Very High
ischemia 5 55.84 Quite High
cerebral cortex 5 38.48 Quite Low
Inflammation 30 5.00 Very Low Very Low Very Low
cytokine 15 5.00 Very Low Very Low Very Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
Spinal cord 5 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 155 99.78 Very High Very High Very High
Central Nervous System Disease 140 98.24 Very High Very High Very High
Neurocysticercosis 115 97.88 Very High Very High Very High
Disease 30 66.88 Quite High
Brain Injury 5 62.88 Quite High
Cv Unclassified Under Development 5 55.84 Quite High
Autoimmune Disease 10 54.08 Quite High
Urological Neuroanatomy 10 34.48 Quite Low
INFLAMMATION 45 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR12 expression was evident in brain tissue cells of both uninfected (Fig. 3A and 3E) and infected mice (Fig. 3B, C, D and 3F).
Gene_expression (expression) of TLR12 in brain
1) Confidence 0.53 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.23 Pain Relevance 0.05
Measurement of mean pixel intensity of TLR12 staining confirmed that parasite infection increased expression of TLR12 protein at 3 wk p.i. in the whole brain (Fig. 3G) as compared to the controls.
Gene_expression (expression) of TLR12 in brain associated with infection
2) Confidence 0.53 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.16 Pain Relevance 0.10
Taken together, the constitutive expression of TLR12 in normal brain and its increased expression during NCC suggest a possible role in CNS function.


Gene_expression (expression) of TLR12 in brain associated with central nervous system and neurocysticercosis
3) Confidence 0.53 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.26 Pain Relevance 0.14
In addition, TLR12 staining was present in brain areas such as the anterior-posterior and external colliculi and pyramidal neurons of the hippocampus (CA1 and CA2).
Gene_expression (present) of TLR12 in pyramidal neurons associated with pyramidal cell and hippocampus
4) Confidence 0.47 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.21 Pain Relevance 0.13
Nevertheless, similar to TLR12, TLR13 expression was predominantly in neurons (Fig. 4E and 4F, yellow/orange color in merged image).



Gene_expression (expression) of TLR12 in neurons
5) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.61 Pain Relevance 0.18

General Comments

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