INT259834

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 3.11
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr13) intracellular (Tlr13) cellular_component (Tlr13)
biological_process (Tlr13)
Anatomy Link Frequency
astrocytes 4
blood vessels 2
Tlr13 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 224 99.12 Very High Very High Very High
Hippocampus 14 97.24 Very High Very High Very High
Pyramidal cell 14 96.48 Very High Very High Very High
cerebral cortex 7 82.40 Quite High
imagery 7 71.96 Quite High
ischemia 7 60.36 Quite High
Spinal cord 7 50.88 Quite High
Inflammation 42 5.00 Very Low Very Low Very Low
cytokine 21 5.00 Very Low Very Low Very Low
Inflammatory response 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 217 100.00 Very High Very High Very High
Central Nervous System Disease 196 99.12 Very High Very High Very High
Neurocysticercosis 161 89.68 High High
Urological Neuroanatomy 14 84.36 Quite High
Pathologic Processes 7 76.48 Quite High
Autoimmune Disease 14 61.68 Quite High
Cv Unclassified Under Development 7 60.36 Quite High
Brain Injury 7 57.00 Quite High
Disease 42 54.84 Quite High
INFLAMMATION 63 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, high upregulation following infection of both TLR2 and TLR13 in astrocytes and their foot processes that terminate at blood vessels may provide necessary signals for initiation of infiltration of immune cells to the CNS and the subsequent adaptive immune response [46].
Positive_regulation (upregulation) of Gene_expression (infection) of TLR13 in blood vessels associated with central nervous system and infection
1) Confidence 0.47 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 1.21 Pain Relevance 0.23
In addition to neurons, increased TLR13 expression was present in other CNS cells including astrocytes (Fig 4G), Purkinje cells, ependymal cells and endothelial cells of pial blood vessels (Fig 4G, arrow points to positive pial vessel).
Positive_regulation (increased) of Gene_expression (expression) of TLR13 in astrocytes associated with central nervous system
2) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.31 Pain Relevance 0.15
Parasite infection produced higher levels of TLR13 protein by several fold (Fig. 4B, C, D, 4F, G and 4H).
Positive_regulation (levels) of Gene_expression (produced) of TLR13 protein associated with infection
3) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.37 Pain Relevance 0.17
In contrast, gene expression of TLR13 was significantly upregulated at all the post infection times tested.
Positive_regulation (upregulated) of Gene_expression (expression) of TLR13 associated with infection
4) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.38 Pain Relevance 0.06
Constitutive mRNA expression was present for each TLR with a relatively higher level of TLR13 gene expression.
Positive_regulation (level) of Gene_expression (expression) of TLR13
5) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.24 Pain Relevance 0.09
A striking increase in TLR13 expression was apparent in terms of both intensity and numbers of astrocytes expressing them.
Positive_regulation (increase) of Gene_expression (expression) of TLR13 in astrocytes
6) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.28 Pain Relevance 0.13
The increased expression of TLR13 at 3 wk p.i. was compared with mock infected mice and expressed as mean pixel intensity (Fig. 4H).
Positive_regulation (increased) of Gene_expression (expression) of TLR13
7) Confidence 0.38 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.32 Pain Relevance 0.15

General Comments

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