INT259835

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 2.83
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr11) intracellular (Tlr11)
Anatomy Link Frequency
neurons 3
brain 2
nervous tissue 1
myeloid cells 1
Tlr11 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 288 90.76 High High
Pyramidal cell 18 5.44 Low Low
Inflammation 54 5.00 Very Low Very Low Very Low
cytokine 27 5.00 Very Low Very Low Very Low
Inflammatory response 27 5.00 Very Low Very Low Very Low
Hippocampus 18 5.00 Very Low Very Low Very Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
Spinal cord 9 5.00 Very Low Very Low Very Low
ketamine 9 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 279 98.88 Very High Very High Very High
Neurocysticercosis 207 98.08 Very High Very High Very High
Urological Neuroanatomy 18 97.68 Very High Very High Very High
Central Nervous System Disease 252 90.76 High High
INFLAMMATION 81 5.00 Very Low Very Low Very Low
Disease 54 5.00 Very Low Very Low Very Low
Autoimmune Disease 18 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low
Brain Injury 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, TLR11 expression in neurons was visible in the stratum pyramidale hippocampi (CA1 and CA2), but not in CA3 neurons.
Gene_expression (expression) of TLR11 in neurons
1) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.40 Pain Relevance 0.04
In the uninfected animals, TLR11 expression was detected at a low basal level mostly in neurons as shown in red color in the insert of a portion of the frame in Fig. 2E (colliculus posterior).
Gene_expression (expression) of TLR11 in neurons
2) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.54 Pain Relevance 0.04
Figure 2l shows upregulated TLR11 protein expression in parasite infected brain at 3 wk p.i.
Gene_expression (expression) of TLR11 protein in brain
3) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.32 Pain Relevance 0.03
At 3 wk p.i. only a small number of infiltrating cells (~5%) expressed TLR11 protein.
Gene_expression (expressed) of TLR11 protein
4) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.17 Pain Relevance 0
The expression in nervous tissue was generally similar to TLR11 expression with respect to cell types and their location.
Gene_expression (expression) of TLR11 in nervous tissue
5) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.16 Pain Relevance 0.05
Morphological, anatomical correlation, and colocalization of TLR11 and Neun staining strongly suggested that the upregulated TLR11 expression was mainly in neurons (Fig. 2F).
Gene_expression (expression) of TLR11 in neurons
6) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.33 Pain Relevance 0.03
In contrast, infiltrating CD11b and CD11c positive myeloid cells predominantly produced TLR11 protein, particularly early during infection at 1 wk post infection (~50% cells).
Gene_expression (produced) of TLR11 protein in myeloid cells associated with infection
7) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2631477 Disease Relevance 0.53 Pain Relevance 0.10
The highest number of infiltrating cells expressed TLR11 in infected brain tissue.
Gene_expression (expressed) of TLR11 in brain
8) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.16 Pain Relevance 0
At 6 wk p.i., TLR11 positive infiltrating cells were barely present.
Gene_expression (present) of TLR11
9) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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