INT259838

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.58
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr13) intracellular (Tlr13) cellular_component (Tlr13)
biological_process (Tlr13)
Anatomy Link Frequency
blood vessels 1
Tlr13 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 4 96.60 Very High Very High Very High
Pyramidal cell 4 95.84 Very High Very High Very High
Central nervous system 64 93.76 High High
cerebral cortex 2 81.76 Quite High
ischemia 2 60.36 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 62 100.00 Very High Very High Very High
Central Nervous System Disease 56 93.76 High High
Neurocysticercosis 46 89.68 High High
Urological Neuroanatomy 4 83.72 Quite High
Pathologic Processes 2 76.48 Quite High
Autoimmune Disease 4 61.68 Quite High
Cv Unclassified Under Development 2 60.36 Quite High
Brain Injury 2 57.00 Quite High
Disease 12 54.84 Quite High
INFLAMMATION 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, high upregulation following infection of both TLR2 and TLR13 in astrocytes and their foot processes that terminate at blood vessels may provide necessary signals for initiation of infiltration of immune cells to the CNS and the subsequent adaptive immune response [46].
Positive_regulation (upregulation) of TLR13 in blood vessels associated with central nervous system and infection
1) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 1.21 Pain Relevance 0.23
Parasite infection produced higher levels of TLR13 protein by several fold (Fig. 4B, C, D, 4F, G and 4H).
Positive_regulation (levels) of TLR13 protein associated with infection
2) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.37 Pain Relevance 0.16

General Comments

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