INT259847

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Context Info
Confidence 0.72
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 20
Disease Relevance 10.37
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr13) intracellular (Tlr13) cellular_component (Tlr13)
biological_process (Tlr13)
Anatomy Link Frequency
brain 5
astrocytes 4
neurons 2
meninges 1
blood vessels 1
Tlr13 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 640 99.28 Very High Very High Very High
Hippocampus 40 97.24 Very High Very High Very High
Pyramidal cell 40 96.48 Very High Very High Very High
cerebral cortex 20 91.44 High High
imagery 20 71.60 Quite High
ischemia 20 69.72 Quite High
Spinal cord 20 50.52 Quite High
Inflammation 120 5.00 Very Low Very Low Very Low
cytokine 60 5.00 Very Low Very Low Very Low
Inflammatory response 60 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 620 100.00 Very High Very High Very High
Central Nervous System Disease 560 99.28 Very High Very High Very High
Neurocysticercosis 460 99.04 Very High Very High Very High
Urological Neuroanatomy 40 93.40 High High
Pathologic Processes 20 76.48 Quite High
Autoimmune Disease 40 71.04 Quite High
Cv Unclassified Under Development 20 69.72 Quite High
Disease 120 66.88 Quite High
Brain Injury 20 66.36 Quite High
INFLAMMATION 180 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR2 and TLR13 were expressed at high levels in almost all CNS cell types both in the uninfected and parasite infected brain.
Gene_expression (expressed) of TLR13 in brain associated with central nervous system
1) Confidence 0.72 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 1.29 Pain Relevance 0.29
However, TLR13 expression was also present in ependymal cells, endothelial cells of pial blood vessels, and astrocytes.
Gene_expression (expression) of TLR13 in ependymal cells
2) Confidence 0.72 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2631477 Disease Relevance 0.53 Pain Relevance 0.11
Among them TLR13 was expressed the most in terms of number of positive cells and brain areas expressing it, followed by TLR11 and TLR12 respectively.
Gene_expression (expressed) of TLR13 in brain
3) Confidence 0.72 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2631477 Disease Relevance 0.54 Pain Relevance 0.13
However, TLR13 seems to be highly expressed in neurons while TLR2 is more abundant in astrocytes.
Gene_expression (expressed) of TLR13 in astrocytes
4) Confidence 0.63 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 1.27 Pain Relevance 0.26
Nevertheless, high upregulation following infection of both TLR2 and TLR13 in astrocytes and their foot processes that terminate at blood vessels may provide necessary signals for initiation of infiltration of immune cells to the CNS and the subsequent adaptive immune response [46].
Gene_expression (infection) of TLR13 in blood vessels associated with central nervous system and infection
5) Confidence 0.63 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 1.20 Pain Relevance 0.23
In comparison to TLR11 and 12, TLR13 expression was present in additional areas including periventricular areas, fissure longitudinalis cerebri and CA3 pyramidal neurons of the hippocampus that were negative for TLR11 and TLR12 staining.
Gene_expression (expression) of TLR13 in pyramidal neurons associated with pyramidal cell and hippocampus
6) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.36 Pain Relevance 0.17
However, a much greater number of neurons expressed TLR13 in these brains (Fig. 4A and 4E, red in the insert e').
Gene_expression (expressed) of TLR13 in brains
7) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.24 Pain Relevance 0.20
A striking increase in TLR13 expression was apparent in terms of both intensity and numbers of astrocytes expressing them.
Gene_expression (expression) of TLR13 in astrocytes
8) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.28 Pain Relevance 0.13
Nevertheless, similar to TLR12, TLR13 expression was predominantly in neurons (Fig. 4E and 4F, yellow/orange color in merged image).



Gene_expression (expression) of TLR13 in neurons
9) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.61 Pain Relevance 0.18
In addition to neurons, increased TLR13 expression was present in other CNS cells including astrocytes (Fig 4G), Purkinje cells, ependymal cells and endothelial cells of pial blood vessels (Fig 4G, arrow points to positive pial vessel).
Gene_expression (expression) of TLR13 in astrocytes associated with central nervous system
10) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.31 Pain Relevance 0.14
The maximum numbers of neurons and astrocytes expressing TLR13 was observed at 3 wk p.i.
Gene_expression (expressing) of TLR13 in astrocytes
11) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.47 Pain Relevance 0.15
In contrast, gene expression of TLR13 was significantly upregulated at all the post infection times tested.
Gene_expression (expression) of TLR13 associated with infection
12) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.37 Pain Relevance 0.06
Parasite infection produced higher levels of TLR13 protein by several fold (Fig. 4B, C, D, 4F, G and 4H).
Gene_expression (produced) of TLR13 protein associated with infection
13) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.37 Pain Relevance 0.17
In mock infected/normal mouse brain, TLR13 was present in some astrocytes in periventricular areas and in proximity to the meninges (data not shown).
Gene_expression (present) of TLR13 in meninges
14) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.30 Pain Relevance 0.15
TLR13 expression was evident in brain tissue cells of both uninfected (Fig. 4A and 4E) and infected mice (Fig. 4B, C, D, 4F and 4G).
Gene_expression (expression) of TLR13 in brain
15) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.26 Pain Relevance 0.13
Among TLRs 11–13, expression of TLR13 was the highest in both normal and parasitic infected brains and remained at an elevated level throughout infection (Fig. 1).
Gene_expression (expression) of TLR13 in brains associated with infection
16) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.40 Pain Relevance 0.03
Constitutive mRNA expression was present for each TLR with a relatively higher level of TLR13 gene expression.
Gene_expression (expression) of TLR13
17) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.23 Pain Relevance 0.09
The increased expression of TLR13 at 3 wk p.i. was compared with mock infected mice and expressed as mean pixel intensity (Fig. 4H).
Gene_expression (expression) of TLR13
18) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.32 Pain Relevance 0.15
However, TLR13 expression was also present in ependymal cells, endothelial cells of pial blood vessels, and astrocytes.
Gene_expression (expression) of TLR13 in endothelial cells
19) Confidence 0.25 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2631477 Disease Relevance 0.53 Pain Relevance 0.11
The maximum numbers of neurons and astrocytes expressing TLR13 was observed at 3 wk p.i.
Gene_expression (expressing) of TLR13 in neurons
20) Confidence 0.19 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.47 Pain Relevance 0.15

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