INT259867

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.70
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCN1A) transmembrane transport (SCN1A)
SCN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 1 87.36 High High
sodium channel 46 86.24 High High
Nav1.1 3 83.68 Quite High
Central nervous system 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
hyperexcitability 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Paroxysmal extreme pain disorder 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 212 98.88 Very High Very High Very High
Epilepsy 118 98.44 Very High Very High Very High
Intellectual Impairment 36 97.92 Very High Very High Very High
Fever 23 96.76 Very High Very High Very High
Learning Disorders 3 96.20 Very High Very High Very High
Convulsion 84 95.92 Very High Very High Very High
Language Development Disorders 9 93.52 High High
Cognitive Disorder 96 91.64 High High
Status Epilepticus 15 85.64 High High
Febrile Convulsions 16 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is due to the fact that some of these entities refer to the family of genes (for example VOLTAGE-GATED POTASSIUM CHANNEL, SCN, CYP), some entities are recognized partly (for example, SCN1 which is a part of SCN1-3A) and others are the synonyms of genes and proteins that are used as abbreviations for other biological entities in the abstracts.
SCN1 Binding (recognized) of
1) Confidence 0.36 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2631582 Disease Relevance 0.23 Pain Relevance 0.09
Patients with PCDH19 and SCN1A mutations had very similar clinical features including the association of early febrile and afebrile seizures, seizures occurring in clusters, developmental and language delays, behavioural disturbances, and cognitive regression.
SCN1A Binding (Patients) of associated with cognitive disorder, convulsion, fever and language development disorders
2) Confidence 0.33 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2633044 Disease Relevance 1.37 Pain Relevance 0
The thirteen patients with PCDH19 mutation or deletion (12 probands and one sib, family 2) all fulfilled the main criteria for DS and were all negative for mutation or rearrangement in SCN1A after direct sequencing and multiplex ligation-dependent probe amplification (MLPA) [15].
SCN1A Binding (ligation) of associated with syndrome
3) Confidence 0.29 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2633044 Disease Relevance 1.21 Pain Relevance 0
They are usually sporadic cases; however, sib pairs with SMEI, or patients with a family history of epilepsy, have occasionally been reported [9].
SMEI Binding (pairs) of associated with epilepsy
4) Confidence 0.28 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2633044 Disease Relevance 1.89 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox