INT259902

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.87
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
blood 2
urine 2
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
peptic ulcer disease 15 99.80 Very High Very High Very High
bradykinin 14 96.48 Very High Very High Very High
Potency 2 76.32 Quite High
Neuropeptide 238 65.68 Quite High
narcan 1 9.84 Low Low
Enkephalin 54 5.00 Very Low Very Low Very Low
Neurotransmitter 30 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Catecholamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 62 99.80 Very High Very High Very High
Cancer 27 99.48 Very High Very High Very High
Proteinuria 85 90.24 High High
Renal Disease 44 72.36 Quite High
Ulcers 14 63.52 Quite High
Diabetes Mellitus 22 60.48 Quite High
Peptic Ulcer 2 46.80 Quite Low
Pheochromocytoma 8 19.20 Low Low
Obstructive Jaundice 1 18.28 Low Low
Stress 11 16.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Third, multiple potential confounders were assessed and found to have no significant effect on the apparent associations between ACE inhibition and PUD and cancer.
Neg (no) Regulation (effect) of Neg (inhibition) Gene_expression (inhibition) of ACE associated with cancer and peptic ulcer disease
1) Confidence 0.45 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2632632 Disease Relevance 1.02 Pain Relevance 0.24
In the single case reported by Warnock (2005), the urine protein excretion was controlled with ACEI/ARB therapy before agalsidase-alfa was started.
Regulation (controlled) of Gene_expression (therapy) of ACEI in urine
2) Confidence 0.44 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 0.71 Pain Relevance 0
The effects of an inhibitor of angiotensin-converting enzyme (ACE) on the profile of these vasoactive peptides illustrated that the drug affects not only its ACE target for angiotensin production but also results in prominent alteration of the profiles of bradykinin and related peptides that regulate blood pressure (Fig. 5) (29).
Regulation (affects) of Gene_expression (target) of ACE in blood associated with bradykinin
3) Confidence 0.20 Published 2010 Journal AAPS J Section Body Doc Link PMC2976990 Disease Relevance 0.14 Pain Relevance 0.46

General Comments

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