INT25991

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Context Info
Confidence 0.53
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.76
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
colon 1
neurons 1
nerve 1
proximal 1
striatum 1
Vip (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 32 100.00 Very High Very High Very High
Enkephalin 21 99.96 Very High Very High Very High
tetrodotoxin 29 99.88 Very High Very High Very High
Crohn's disease 25 99.56 Very High Very High Very High
Hippocampus 4 99.28 Very High Very High Very High
Substantia nigra 4 98.68 Very High Very High Very High
pruritus 59 97.44 Very High Very High Very High
Neuropeptide 42 96.36 Very High Very High Very High
Inflammation 132 96.24 Very High Very High Very High
Calcitonin gene-related peptide 7 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 96 99.84 Very High Very High Very High
Convulsion 24 99.60 Very High Very High Very High
Disease 60 99.56 Very High Very High Very High
Pruritus 78 97.44 Very High Very High Very High
INFLAMMATION 135 96.24 Very High Very High Very High
Colitis 60 91.64 High High
Heart Disease 1 91.52 High High
Syndrome 4 90.32 High High
Parkinson's Disease 2 89.64 High High
Lifespan 1 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SP, Enk, VIP, PHI, and BLIP levels were all decreased in the distal colon of piebald mice as compared to normal littermates, SP, BLIP, and Enk levels were also decreased in the dilated proximal colon of piebald mice.
Negative_regulation (decreased) of VIP in proximal associated with enkephalin and substance p
1) Confidence 0.53 Published 1985 Journal J. Surg. Res. Section Abstract Doc Link 3990276 Disease Relevance 0.24 Pain Relevance 0.70
Conversely these findings might suggest that a defect in specific PACAP/VIP function could act adversely on SN cells and, perhaps in concert with other environmental factors, contribute to a clinical presentation consistent with PD.
Negative_regulation (defect) of VIP associated with substantia nigra and disease
2) Confidence 0.45 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.22 Pain Relevance 0.25
A detailed time-course study revealed that seizures in El mice caused (1) significant decreases in levels of ME-LI in the striatum and hippocampus during seizures, (2) a significant decrease of VIP-LI content in the striatum 3 hours after seizures, and (3) a significant increase in hypothalamic VIP-LI 9 hours after seizures.
Negative_regulation (decrease) of VIP in striatum associated with convulsion, hippocampus and enkephalin
3) Confidence 0.42 Published 1988 Journal Neurochem. Res. Section Abstract Doc Link 3216955 Disease Relevance 1.00 Pain Relevance 0.73
Inhibition of AA metabolites of the lipoxygenase pathway by nordihydroguaiaretic acid, 5,8,11,14-eicosatetranoic acid, and caffeic acid results in a concentration-dependent inhibition of VIP release evoked by 4-AP.
Negative_regulation (inhibition) of VIP
4) Confidence 0.35 Published 1989 Journal J. Neurosci. Section Abstract Doc Link 2545840 Disease Relevance 0 Pain Relevance 0.42
In mutant mice that lack VIP [11]–[13] or the VPAC2 subtype of VIP receptor (Vipr2?
Negative_regulation (lack) of VIP
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842429 Disease Relevance 0.56 Pain Relevance 0
Then, we simulated loss of VIP and VPAC2 receptor [13,18,19] by lowering the coupling strength and reducing the range of connectivity, and showed that oscillators were slowly desynchronized and damped (Figure 3F).
Negative_regulation (loss) of VIP
6) Confidence 0.28 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1851983 Disease Relevance 0 Pain Relevance 0.13
We studied the synchronization dynamics of coupled SCN neurons under four different conditions: high-density culture, low-density culture, presence of TTX, and loss of VIP/VPAC2 receptor.
Negative_regulation (loss) of VIP in neurons associated with tetrodotoxin
7) Confidence 0.28 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1851983 Disease Relevance 0 Pain Relevance 0.10
Vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM)-containing nerve fibers were decreased; however, substance P- and leucine enkephalin (Leu-ENK)-containing fibers were increased.
Negative_regulation (decreased) of Vasoactive intestinal polypeptide in nerve associated with enkephalin and substance p
8) Confidence 0.26 Published 1989 Journal J. Pediatr. Surg. Section Abstract Doc Link 2593057 Disease Relevance 0.17 Pain Relevance 0.15
between pruritics and nonpruritics, however, a tendency to lower SP and VIP
Negative_regulation (lower) of VIP associated with substance p
9) Confidence 0.16 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2221678 Disease Relevance 0.82 Pain Relevance 0.89
A detailed time-course study revealed that seizures in El mice caused (1) significant decreases in levels of ME-LI in the striatum and hippocampus during seizures, (2) a significant decrease of VIP-LI content in the striatum 3 hours after seizures, and (3) a significant increase in hypothalamic VIP-LI 9 hours after seizures.
Negative_regulation (decrease) of VIP in hippocampus associated with convulsion, hippocampus and enkephalin
10) Confidence 0.14 Published 1988 Journal Neurochem. Res. Section Abstract Doc Link 3216955 Disease Relevance 1.00 Pain Relevance 0.73
In contrast, Mazumdar and Das found decreased expression of VIP immunoreactivity in the colon of both CD and UC patients, compared to controls [52], while two other studies showed a significant decreased of rectal and colonic VIP in UC and CD patients.
Negative_regulation (decreased) of VIP in colon associated with inflammatory bowel disease and crohn's disease
11) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.74 Pain Relevance 0.54

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