INT259916

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.32
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
MSCs 2
astrocytes 2
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 27 92.56 High High
Inflammation 18 61.52 Quite High
cINOD 3 46.96 Quite Low
ischemia 15 5.00 Very Low Very Low Very Low
isoflurane 12 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 51 99.68 Very High Very High Very High
Stroke 81 93.64 High High
Cicatrix 12 70.28 Quite High
Apoptosis 24 66.00 Quite High
Neurodegenerative Disease 9 63.12 Quite High
INFLAMMATION 21 61.52 Quite High
Disease 12 45.04 Quite Low
Targeted Disruption 18 39.92 Quite Low
Brain Injury 3 38.48 Quite Low
Injury 6 6.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This enhanced tPA activity may increase active neurotrophins [48]–[50], [86].
Spec (may) Positive_regulation (increase) of Positive_regulation (enhanced) of tPA
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.44 Pain Relevance 0.07
Using LCM, we have demonstrated that astrocytes in the IBZ respond to MSC treatment by increasing tPA activity (i.e. increase of tPA level with a concomitant decrease of PAI-1 level).
Positive_regulation (increasing) of Positive_regulation (increase) of tPA in astrocytes
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.40 Pain Relevance 0
In vivo, administration of MSCs to mice subjected to middle cerebral artery occlusion (MCAo) significantly increased activation of tPA and downregulated PAI-1 levels in the ischemic boundary zone (IBZ) compared with control PBS treated mice, concurrently with increases of myelinated axons and synaptophysin.
Positive_regulation (increased) of Positive_regulation (activation) of tPA in MSCs associated with middle cerebral artery infarction
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2815778 Disease Relevance 0.37 Pain Relevance 0.09
Clearly, structures of inhibitors or enhancers of the TPA-induced activation of AP-1 can differ considerable from a strict trans-stilbene scaffold.


Positive_regulation (induced) of Positive_regulation (activation) of TPA
4) Confidence 0.07 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.11 Pain Relevance 0.06
By comparison, 7, which is isomeric with 1, enhanced the TPA-induced activation of AP-1 2.5-fold.
Positive_regulation (induced) of Positive_regulation (activation) of TPA
5) Confidence 0.07 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
By comparison, 7, which is isomeric with 1, enhanced the TPA-induced activation of AP-1 2.5-fold.
Positive_regulation (enhanced) of Positive_regulation (activation) of TPA
6) Confidence 0.07 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0

General Comments

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