INT259927

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.78
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) peptidase activity (Plat) extracellular space (Plat)
extracellular region (Plat) nucleus (Jun) DNA binding (Jun)
Anatomy Link Frequency
HT-29 2
Plat (Mus musculus)
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 18 70.56 Quite High
metalloproteinase 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 9 98.92 Very High Very High Very High
Breast Cancer 9 95.00 High High
Stress 12 73.84 Quite High
Apoptosis 9 71.52 Quite High
INFLAMMATION 21 70.56 Quite High
Disease 9 64.56 Quite High
Skin Cancer 6 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substituted trans-stilbenes represent a class of compounds that can inhibit or enhance the TPA-induced activation of AP-1.
Positive_regulation (enhance) of TPA Positive_regulation (activation) of AP-1
1) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.40 Pain Relevance 0.04
In HT-29 cancer cells transfected with an AP-1 reporter, resveratrol enhanced AP-1 activity induced by TPA, similar to the present study [30].
Positive_regulation (enhanced) of TPA Positive_regulation (induced) of AP-1 in HT-29 associated with cancer
2) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.38 Pain Relevance 0
None of the trans-stilbenes in this group enhanced the TPA-induced activation of AP-1.
Positive_regulation (enhanced) of TPA Positive_regulation (activation) of AP-1
3) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0

General Comments

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