INT259931

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) peptidase activity (Plat) extracellular space (Plat)
extracellular region (Plat) nucleus (Jun) DNA binding (Jun)
Anatomy Link Frequency
skin 4
Plat (Mus musculus)
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 86.60 High High
cytokine 4 59.84 Quite High
cINOD 2 28.76 Quite Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 4 97.48 Very High Very High Very High
Stress 8 93.52 High High
Apoptosis 6 88.48 High High
INFLAMMATION 14 86.60 High High
Cancer 6 73.96 Quite High
Breast Cancer 6 30.32 Quite Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resveratrol inhibited the TPA-induced expression of c-Fos and c-Jun in mouse skin, also by inhibiting MAP kinases [18,19].
TPA Positive_regulation (induced) of Gene_expression (expression) of c-Jun in skin
1) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.30 Pain Relevance 0.07
In addition to suppressing TNF-induced activation of AP-1 in a variety of cells, inhibiting TPA-induced expression of c-Fos and c-Jun in mouse skin, and inhibiting anchorage-independent growth of melanoma cells [18-20], resveratrol suppressed TPA-induced expression of MMP-9 by inhibition of AP-1 activation through c-Jun N-terminal kinase (JNK) and PKC-delta pathways [26] and protected against 4-hydroxynonenal-induced apoptosis by blocking AP-1 signaling through JNK [27].
TPA Positive_regulation (induced) of Gene_expression (expression) of c-Jun in skin associated with apoptosis and skin cancer
2) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.28 Pain Relevance 0

General Comments

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