INT259934

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat, Mmp9) extracellular space (Plat, Mmp9) extracellular region (Plat, Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
skin 2
Plat (Mus musculus)
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 6 99.12 Very High Very High Very High
ischemia 12 50.00 Quite Low
Eae 1 47.76 Quite Low
cINOD 1 22.72 Low Low
Inflammation 7 20.48 Low Low
aspirin 2 6.88 Low Low
metalloproteinase 17 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cerebral Edema 10 99.76 Very High Very High Very High
Skin Cancer 2 99.22 Very High Very High Very High
Cv General 3 Under Development 3 99.12 Very High Very High Very High
Apoptosis 7 94.12 High High
Hemorrhage 2 88.56 High High
Stress 4 87.48 High High
Cv General 4 Under Development 6 80.32 Quite High
Injury 7 77.16 Quite High
Brain Injury 3 74.72 Quite High
Brain Hemorrhage 9 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of MMP-9 was remarkably upregulated by tPA (Fig. 3C).
tPA Positive_regulation (upregulated) of Gene_expression (expression) of MMP-9
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997776 Disease Relevance 0.77 Pain Relevance 0.17
In addition to suppressing TNF-induced activation of AP-1 in a variety of cells, inhibiting TPA-induced expression of c-Fos and c-Jun in mouse skin, and inhibiting anchorage-independent growth of melanoma cells [18-20], resveratrol suppressed TPA-induced expression of MMP-9 by inhibition of AP-1 activation through c-Jun N-terminal kinase (JNK) and PKC-delta pathways [26] and protected against 4-hydroxynonenal-induced apoptosis by blocking AP-1 signaling through JNK [27].
TPA Positive_regulation (induced) of Gene_expression (expression) of MMP-9 in skin associated with apoptosis and skin cancer
2) Confidence 0.02 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.28 Pain Relevance 0

General Comments

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