INT259937

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.69
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CSK, PTPN22) cytosol (CSK) Golgi apparatus (CSK)
nucleus (PTPN22) plasma membrane (CSK)
CSK (Homo sapiens)
PTPN22 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 3 65.52 Quite High
spinal inflammation 42 56.36 Quite High
Multiple sclerosis 3 49.36 Quite Low
Inflammation 6 40.64 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 24 99.76 Very High Very High Very High
Uveitis 177 71.52 Quite High
Rheumatoid Arthritis 3 65.52 Quite High
Diabetes Mellitus 6 63.76 Quite High
Systemic Lupus Erythematosus 3 61.68 Quite High
Thyroiditis 3 58.96 Quite High
Low Back Pain 42 56.36 Quite High
Demyelinating Disease 3 49.36 Quite Low
Disease 33 46.88 Quite Low
INFLAMMATION 6 40.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTPN22 is located on chromosome 1p13.3 and encodes a lymphoid-specific phosphatase (Lyp) that binds to c-src tyrosine kinase (Csk), an intracellular tyrosine kinase.
Csk Binding (binds) of Lyp
1) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2632733 Disease Relevance 0.47 Pain Relevance 0.05
PTPN22 is located on chromosome 1p13.3 and encodes a lymphoid-specific phosphatase (Lyp) that binds to c-src tyrosine kinase (Csk), an intracellular tyrosine kinase.
Csk Binding (binds) of PTPN22
2) Confidence 0.16 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2632733 Disease Relevance 0.65 Pain Relevance 0.16
The PTPN22 R620W mutation leads to reduced binding of Lyp to Csk, resulting in reduced Lck inactivation, with the overall effect of a gain of function mutation.
Csk Binding (binding) of Lyp
3) Confidence 0.16 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2632733 Disease Relevance 0.57 Pain Relevance 0.03

General Comments

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