INT259939

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CSK, PTPN22) cytosol (CSK) Golgi apparatus (CSK)
nucleus (PTPN22) plasma membrane (CSK)
CSK (Homo sapiens)
PTPN22 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 65.52 Quite High
Multiple sclerosis 1 49.36 Quite Low
spinal inflammation 14 43.88 Quite Low
Inflammation 2 28.16 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 8 87.28 High High
Rheumatoid Arthritis 1 65.52 Quite High
Diabetes Mellitus 2 63.76 Quite High
Systemic Lupus Erythematosus 1 61.68 Quite High
Uveitis 59 59.04 Quite High
Thyroiditis 1 58.96 Quite High
Demyelinating Disease 1 49.36 Quite Low
Disease 11 46.88 Quite Low
Low Back Pain 14 43.88 Quite Low
INFLAMMATION 2 28.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PTPN22 R620W mutation leads to reduced binding of Lyp to Csk, resulting in reduced Lck inactivation, with the overall effect of a gain of function mutation.
Negative_regulation (reduced) of Csk Binding (binding) of Lyp
1) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2632733 Disease Relevance 0.62 Pain Relevance 0.03

General Comments

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