INT25998

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.47
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SSRP1) chromosome (SSRP1) nucleus (SSRP1)
DNA binding (SSRP1) cytoplasm (SSRP1)
Anatomy Link Frequency
neurite 2
bladder 1
SSRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 13 73.04 Quite High
cva 1 67.44 Quite High
peripheral neuropathy 5 49.28 Quite Low
Pain 3 43.76 Quite Low
Potency 4 39.48 Quite Low
Nerve growth factor 14 25.68 Quite Low
imagery 13 5.00 Very Low Very Low Very Low
induced neuropathy 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 67 99.64 Very High Very High Very High
Ovarian Cancer 38 98.48 Very High Very High Very High
Bladder Cancer 1 94.72 High High
Cancer 105 90.56 High High
Increased Venous Pressure Under Development 1 78.32 Quite High
Aneurism 1 76.16 Quite High
Small Cell Lung Cancer 7 70.16 Quite High
Hemorrhage 1 68.40 Quite High
Cv General 3 Under Development 1 67.44 Quite High
Urinary Tract Infection 1 63.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an attempt to increase the therapeutic index of Cisplatin (CDDP), 29 continuous 48 hour intra-arterial (IA) infusions of 100-150 mg/m2 CDDP were given to 26 patients with bulky stage T3-T4 bladder cancer.
Positive_regulation (increase) of Cisplatin in bladder associated with bladder cancer
1) Confidence 0.43 Published 1989 Journal J Surg Oncol Section Abstract Doc Link 2545974 Disease Relevance 0.51 Pain Relevance 0.03
M) or Cisplatin alone had no effect on neurite length, the combination of these drugs increased neurite length compared to Cisplatin alone (* p < 0.001), reflecting a blocking of Cisplatin neurite toxicity.
Positive_regulation (increased) of Cisplatin in neurite associated with toxicity
2) Confidence 0.17 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950519 Disease Relevance 0.51 Pain Relevance 0
The ability of PXD to protect against Cisplatin induced neurite toxicity is likely reflected in the mechanism by which it produces neurite toxicity.
Positive_regulation (induced) of Cisplatin in neurite associated with toxicity
3) Confidence 0.17 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950519 Disease Relevance 0.86 Pain Relevance 0
Of the 55 genes upregulated more than fourfold in oxoplatin-treated H526 cells only three genes, namely, HIST2H2BE, PNUTL2, and AKR1C3, were in common with those genes upregulated in cisplatin-treated cells (the 27 genes exhibiting the strongest increases in expression triggered by oxoplatin are shown in Table 1).
Positive_regulation (upregulated) of cisplatin
4) Confidence 0.04 Published 2009 Journal Metal-Based Drugs Section Body Doc Link PMC2705772 Disease Relevance 0.16 Pain Relevance 0
Thus, we have shown that the anti-tumoral and cisplatin-sensitization activities of NCX-4040 were closely linked to its capacity to release NO in the ovarian cancer cells.
Positive_regulation (linked) of cisplatin associated with ovarian cancer
5) Confidence 0.01 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 0.43 Pain Relevance 0.04

General Comments

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