INT260067

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (XPA) signal transduction (PTCH1) Golgi apparatus (PTCH1)
nucleus (XPA) plasma membrane (PTCH1)
Anatomy Link Frequency
stem cell 1
PTCH1 (Homo sapiens)
XPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Hsan 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 165 99.24 Very High Very High Very High
Skin Cancer 48 97.40 Very High Very High Very High
Basal Cell Nevus Syndrome 15 78.00 Quite High
Cancer 78 70.64 Quite High
Death 3 59.64 Quite High
Disease 9 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Fanconi Anemia 6 5.00 Very Low Very Low Very Low
Pancreatic Cancer 6 5.00 Very Low Very Low Very Low
Freckles 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant association between PTCH1 and XPA deletion in both groups as well as between their methylation in group-B suggested some functional relationship between hedgehog dependent stem cell renewal pathway and the NER pathway.
PTCH1 Spec (suggested) Binding (association) of XPA in stem cell
1) Confidence 0.26 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.38 Pain Relevance 0
Deletion between PTCH1 and XPA was significantly associated in both group-A (P = 0.02) and group-B (P = 0.00003) [Table 3].


PTCH1 Binding (associated) of XPA
2) Confidence 0.26 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.35 Pain Relevance 0
Overall alterations of PTCH1 showed significant association with XPA in both group-A (P = 0.003) and group-B (P = 0.007).
PTCH1 Binding (association) of XPA
3) Confidence 0.22 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.35 Pain Relevance 0

General Comments

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