INT260074

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (BRCA2) Golgi apparatus (PTCH1) DNA binding (BRCA2)
protein complex (BRCA2) cytoplasm (BRCA2) signal transduction (PTCH1)
Anatomy Link Frequency
stem cell 1
BRCA2 (Homo sapiens)
PTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hsan 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 55 100.00 Very High Very High Very High
Cancer 26 33.76 Quite Low
Skin Cancer 16 5.00 Very Low Very Low Very Low
Basal Cell Nevus Syndrome 5 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low
Fanconi Anemia 2 5.00 Very Low Very Low Very Low
Pancreatic Cancer 2 5.00 Very Low Very Low Very Low
Freckles 2 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis and dysregulation of multiple DNA repair pathways as well as hedgehog dependent stem cell renewal pathway.



BRCA2 Binding (association) of PTCH1 in stem cell associated with breast cancer
1) Confidence 0.40 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2633285 Disease Relevance 0.15 Pain Relevance 0

General Comments

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