INT260083

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.46
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PTCH1) Golgi apparatus (PTCH1) plasma membrane (PTCH1)
Anatomy Link Frequency
stem cell 1
PTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 1 60.64 Quite High
rheumatoid arthritis 56 53.68 Quite High
cytokine 13 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
Hsan 9 5.00 Very Low Very Low Very Low
cryotherapy 9 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 38 99.12 Very High Very High Very High
Breast Cancer 495 98.72 Very High Very High Very High
Basal Cell Nevus Syndrome 47 97.36 Very High Very High Very High
Syndrome 5 97.12 Very High Very High Very High
Cancer 249 94.56 High High
Skin Cancer 205 86.56 High High
Sunburn 3 81.12 Quite High
Repression 3 74.64 Quite High
Metastasis 20 71.60 Quite High
Apoptosis 25 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to XPA, overall frequencies of alterations in PHF2, FANCC and PTCH1 were higher (Figure 4).
Regulation (alterations) of PTCH1
1) Confidence 0.27 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.48 Pain Relevance 0
Table 5 indicates significant association between alterations of FANCC (P = 0.004) and PTCH1 (P = 0.001) genes with their protein expression as seen by immunohistochemistry.
Regulation (alterations) of PTCH1
2) Confidence 0.27 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.43 Pain Relevance 0
However, only in group-A, significant association was observed between overall alterations of PTCH1 and deletion of BRCA1 (P = 0.04) [Additional File 6].


Regulation (alterations) of PTCH1
3) Confidence 0.27 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.39 Pain Relevance 0
Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis and dysregulation of multiple DNA repair pathways as well as hedgehog dependent stem cell renewal pathway.



Regulation (alterations) of PTCH1 in stem cell associated with breast cancer
4) Confidence 0.27 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2633285 Disease Relevance 0.15 Pain Relevance 0
Similar result was also seen with PTCH1 and XPA alterations in group-A and PHF2 alterations in group-B.
Regulation (alterations) of PTCH1
5) Confidence 0.27 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2633285 Disease Relevance 0.19 Pain Relevance 0
Contrary to previous reports, frequencies of alterations in PTCH1 in our samples were higher [9].
Regulation (alterations) of PTCH1
6) Confidence 0.27 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.35 Pain Relevance 0
Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: Pathological significance in early- and late-onset breast carcinoma

Introduction

Regulation (Alterations) of PTCH1 associated with breast cancer
7) Confidence 0.27 Published 2008 Journal Mol Cancer Section Title Doc Link PMC2633285 Disease Relevance 0.58 Pain Relevance 0
Overall alterations of PHF2, FANCC and PTCH1 were comparatively higher than XPA.
Regulation (alterations) of PTCH1
8) Confidence 0.27 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2633285 Disease Relevance 0.15 Pain Relevance 0
Either age group exhibited high frequency of overall alterations in PHF2, FANCC and PTCH1 compared to XPA.
Regulation (alterations) of PTCH1
9) Confidence 0.27 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2633285 Disease Relevance 0.26 Pain Relevance 0
As many genes such as IRAK1, IRAK2, TRAF6, FADD, IRF-5, STAT-1 and PTC1 have been found to be targets of miR-146a in human disease [20,31,34,46], the targets and functions of miR-146a may be different in specific cells.
Regulation (targets) of PTC1 associated with disease
10) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.36 Pain Relevance 0.03
PTCH gene is the human homologue of the drosophilia patched gene, negatively regulating Hedgehog signalling via inhibition of Smoothened (Smo), a transmembrane protein.
Regulation (regulating) of PTCH gene
11) Confidence 0.06 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989864 Disease Relevance 1.13 Pain Relevance 0.06

General Comments

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