INT260111

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.46
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ISG20) nucleoplasm (ISG20) RNA binding (ISG20)
nucleus (ISG20) intracellular (ISG20)
Anatomy Link Frequency
regulatory T cells 3
T cells 1
ISG20 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 27 99.76 Very High Very High Very High
Inflammation 99 99.28 Very High Very High Very High
tolerance 24 91.20 High High
Arthritis 54 86.32 High High
chemokine 15 83.56 Quite High
cytokine 99 72.04 Quite High
Potency 3 66.00 Quite High
methotrexate 9 63.12 Quite High
Neuritis 2 57.56 Quite High
corticosteroid 6 22.44 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 27 99.76 Very High Very High Very High
INFLAMMATION 99 99.28 Very High Very High Very High
Systemic Lupus Erythematosus 39 99.00 Very High Very High Very High
Disease 54 98.84 Very High Very High Very High
Juvenile Chronic Polyarthritis 48 86.32 High High
Death 2 84.24 Quite High
Kidney Stones 6 74.36 Quite High
Hypercalcemia 10 72.28 Quite High
Toxicity 2 70.64 Quite High
Autoimmune Disease 46 64.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treg [19], and CD4+CD25?
Localization (Treg) of CD25
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001453 Disease Relevance 0.22 Pain Relevance 0
treated resting memory CD4+ T cells (Fig 3A), it is not totally unexpected that addition of IL-2 to cultures of resting memory CD4+CD25?
Localization (cultures) of CD25 in T cells
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.22 Pain Relevance 0.14
We separated CD4+CD25?
Localization (separated) of CD25
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.17 Pain Relevance 0.09
Thus, CD4+CD25high regulatory T cells may be actively recruited or be generated de novo at sites of inflammation (or both).
Localization (recruited) of CD25high in regulatory T cells associated with inflammation
4) Confidence 0.23 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.88 Pain Relevance 0.41
Numbers of circulating CD4+CD25high regulatory T cells decrease in patients with active SLE [125-127] while clinical remission is associated with elevated or normal CD4+CD25high regulatory T cell frequency [128-131].
Localization (decrease) of CD25high in regulatory T cell associated with systemic lupus erythematosus
5) Confidence 0.23 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.18 Pain Relevance 0.21
CD4+CD25high regulatory T cells from RA subjects are capable of suppressing the production of IFN-?
Localization (regulatory T cells) of CD25high in regulatory T cells associated with rheumatoid arthritis
6) Confidence 0.23 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.80 Pain Relevance 0.41

General Comments

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