INT260114

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.98
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ISG20) nucleoplasm (ISG20) RNA binding (ISG20)
nucleus (ISG20) intracellular (ISG20)
Anatomy Link Frequency
regulatory T cells 4
synovial fluid 1
ISG20 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 90 99.56 Very High Very High Very High
Arthritis 284 98.94 Very High Very High Very High
corticosteroid 8 97.00 Very High Very High Very High
methotrexate 24 96.28 Very High Very High Very High
Osteoarthritis 4 82.64 Quite High
Inflammation 122 72.20 Quite High
chemokine 22 59.56 Quite High
tolerance 32 30.64 Quite Low
rheumatoid arthritis 38 6.52 Low Low
abatacept 4 5.92 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 242 98.94 Very High Very High Very High
Systemic Lupus Erythematosus 58 98.82 Very High Very High Very High
Systemic Sclerosis 6 98.66 Very High Very High Very High
Sjoegrens Syndrome 8 98.52 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 8 94.16 High High
Rheumatic Diseases 48 89.16 High High
Disease 88 88.24 High High
Lymphatic System Cancer 2 85.68 High High
Leukemia 10 84.80 Quite High
Autoimmune Disease 70 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum and synovial fluid from RA patients stimulated TLR4 expressing CHO cells to up-regulate CD25, but the serum and synovial fluid from the healthy donors had no effect on CHO cells.
Regulation (regulate) of CD25 in synovial fluid associated with arthritis
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 1.49 Pain Relevance 0.33
Furthermore, the serum from SSc and SLE patients cannot stimulate TLR4 expressing CHO cells to up-regulate CD25, which suggests that TLR4 could be a specific biomarker for RA [111].
Regulation (regulate) of CD25 associated with systemic lupus erythematosus, systemic sclerosis and arthritis
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 1.58 Pain Relevance 0.34
However, a more recent report argues that the numbers of circulating CD4+CD25high regulatory T cells in patients with Sjogren syndrome decrease [137].
Regulation (circulating) of CD25high in regulatory T cells associated with sjoegrens syndrome
3) Confidence 0.16 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.19 Pain Relevance 0.10
Besides these established therapies, recent research has focused on cytokine related therapies to modulate CD4+CD25high regulatory T cell function.
Regulation (modulate) of CD25high in regulatory T cell associated with cytokine
4) Confidence 0.14 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.25 Pain Relevance 0.21
Use of IL-2, a T cell growth factor that induces proliferation of CD4+CD25high regulatory T cells in vitro, was considered.
Regulation (proliferation) of CD25high in regulatory T cells
5) Confidence 0.14 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.31 Pain Relevance 0.07
These cytokines signal via STAT5, the homeostatic pathway that regulates CD4+CD25high regulatory T cell function.
Regulation (regulates) of CD25high in regulatory T cell associated with cytokine
6) Confidence 0.10 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.17 Pain Relevance 0.22

General Comments

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