INT260115

Context Info Confidence 0.29 First Reported 2008 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.75 Pain Relevance 0.34

growth (FOXP3) nucleus (FOXP3) intracellular (FOXP3) embryo development (FOXP3) protein complex (FOXP3) cytoplasm (FOXP3)

Anatomy Link Frequency Th17 cells 1 nTreg 1 regulatory T cell 1 T-cell 1 FOXP3 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 62 98.42 rheumatoid arthritis 148 80.80 Inflammation 77 78.48 Osteoarthritis 50 47.20 tolerance 21 5.00 Arthritis 18 5.00 chemokine 8 5.00 Multiple sclerosis 6 5.00 methotrexate 5 5.00 cINOD 4 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 149 80.80 INFLAMMATION 77 78.48 Apoptosis 7 70.88 Cancer 42 65.84 Arthritis 6 54.16 Rheumatic Diseases 14 50.00 Osteoarthritis 48 47.20 Colon Cancer 6 37.20 Solid Tumor 2 25.92 Syndrome 5 21.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These evidences show the importance of cytokines environment in the differentiation of CD4+ T-cell subsets, depending upon the balance of expression of the transcriptional factors RORgammat and FoxP3.

Regulation (balance) of FoxP3 in T-cell associated with cytokine

1) Confidence 0.29 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.20 Pain Relevance 0.13

Foxp3 is the transcription factor controlling regulatory T cell development[37], while, ROR?

Regulation (controlling) of Foxp3 in regulatory T cell

2) Confidence 0.21 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0.34 Pain Relevance 0.14

Real-time PCR was performed to examine the expression of the important factors in the differentiation of human Th17 cells, including Foxp3, ROR?

Spec (examine) Regulation (important) of Foxp3 in Th17 cells

3) Confidence 0.21 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0.06 Pain Relevance 0.03

However, the signals that induce the stable up-regulation of Foxp3 and committed regulatory function in nTreg are not known.

Regulation (regulation) of Foxp3 in nTreg

4) Confidence 0.19 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.15 Pain Relevance 0.04

General Comments

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