INT260116

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.68
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR4) signal transducer activity (CCR4)
Anatomy Link Frequency
regulatory T cells 2
CCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 42 100.00 Very High Very High Very High
chemokine 10 100.00 Very High Very High Very High
Arthritis 36 96.64 Very High Very High Very High
rheumatoid arthritis 18 92.96 High High
methotrexate 6 81.56 Quite High
corticosteroid 4 40.88 Quite Low
tolerance 16 26.08 Quite Low
cytokine 28 5.00 Very Low Very Low Very Low
abatacept 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 42 100.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 32 96.64 Very High Very High Very High
Rheumatoid Arthritis 18 92.96 High High
Rheumatic Diseases 24 50.00 Quite Low
Systemic Lupus Erythematosus 26 30.64 Quite Low
Disease 32 17.28 Low Low
Autoimmune Disease 30 5.00 Very Low Very Low Very Low
Sarcoidosis 8 5.00 Very Low Very Low Very Low
Graft Vs Host Disease 8 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These synovial CD4+CD25high regulatory T cells express increased levels of inflammation-related chemokine receptors, such as CCR4, CCR5, and CXCR4 [120].
Positive_regulation (increased) of CCR4 in regulatory T cells associated with chemokine and inflammation
1) Confidence 0.22 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.84 Pain Relevance 0.51
These synovial CD4+CD25high regulatory T cells express increased levels of inflammation-related chemokine receptors, such as CCR4, CCR5, and CXCR4 [120].
Positive_regulation (levels) of CCR4 in regulatory T cells associated with chemokine and inflammation
2) Confidence 0.15 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.84 Pain Relevance 0.51

General Comments

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