INT260118

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.66
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
juvenile 2
regulatory T cells 2
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 36 99.92 Very High Very High Very High
Inflammation 42 77.56 Quite High
chemokine 10 64.92 Quite High
Multiple sclerosis 2 47.52 Quite Low
cytokine 28 5.00 Very Low Very Low Very Low
rheumatoid arthritis 18 5.00 Very Low Very Low Very Low
tolerance 16 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
abatacept 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Juvenile Chronic Polyarthritis 32 99.92 Very High Very High Very High
Congenital Anomalies 4 97.52 Very High Very High Very High
Rheumatic Diseases 24 96.24 Very High Very High Very High
Disease 32 95.36 Very High Very High Very High
INFLAMMATION 42 77.56 Quite High
Graft Vs Host Disease 8 71.92 Quite High
Autoimmune Disease 30 57.96 Quite High
Diabetes Mellitus 6 48.20 Quite Low
Demyelinating Disease 2 47.52 Quite Low
Apoptosis 4 42.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Research on CD4+CD25high regulatory T cells in juvenile idiopathic arthritis (JIA) has revealed distinct abnormalities in function and distribution in various disease subtypes.
Regulation (Research) of Regulation (regulatory T cells) of CD4 in juvenile associated with congenital anomalies, disease, juvenile chronic polyarthritis and arthritis
1) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.38 Pain Relevance 0.31
Thus, strategies to expand CD4+CD25high regulatory T cells for higher yield and purity have been sought.
Regulation (expand) of Regulation (regulatory T cells) of CD4 in regulatory T cells
2) Confidence 0.44 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.28 Pain Relevance 0.10

General Comments

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