INT260120

Context Info Confidence 0.31 First Reported 2008 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.74 Pain Relevance 0.29

growth (FOXP3) nucleus (FOXP3) intracellular (FOXP3) embryo development (FOXP3) protein complex (FOXP3) cytoplasm (FOXP3)

Anatomy Link Frequency regulatory T cells 4 Th17 cells 2 T cells 2 FOXP3 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 48 68.72 tolerance 24 60.44 rheumatoid arthritis 96 58.80 methotrexate 10 54.00 corticosteroid 6 52.72 Osteoarthritis 25 47.20 Arthritis 54 21.24 chemokine 15 18.48 Inflammation 75 17.76 Multiple sclerosis 5 5.00

Disease Link Frequency Relevance Heat Systemic Lupus Erythematosus 39 99.84 Disease 74 97.12 Lymphopenia 3 82.92 Rheumatic Diseases 37 74.48 Autoimmune Disease 45 65.92 Sjoegrens Syndrome 6 64.72 Rheumatoid Arthritis 96 58.80 Osteoarthritis 24 47.20 Mucocutaneous Lymph Node Syndrome 6 37.84 Fever 6 21.92

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Yan et al. found no difference in Foxp3 expression in CD4+CD25high regulatory T cells of SLE patients [134].

Regulation (regulatory T cells) of Gene_expression (expression) of Foxp3 in regulatory T cells associated with systemic lupus erythematosus

1) Confidence 0.31 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.27 Pain Relevance 0.11

Yan et al. found no difference in Foxp3 expression in CD4+CD25high regulatory T cells of SLE patients [134].

Neg (no) Regulation (difference) of Gene_expression (expression) of Foxp3 in regulatory T cells associated with systemic lupus erythematosus

2) Confidence 0.31 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.26 Pain Relevance 0.08

Real-time PCR was performed to examine the expression of the important factors in the differentiation of human Th17 cells, including Foxp3, ROR?

Spec (examine) Regulation (examine) of Spec (examine) Gene_expression (expression) of Foxp3 in Th17 cells

3) Confidence 0.21 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0.06 Pain Relevance 0.03

In addition, activation of CD4+CD25- T cells can transiently up-regulate FoxP3 expression in human cells, although this is not the case in mice [41,52,53].

Regulation (regulate) of Gene_expression (expression) of FoxP3 in T cells

4) Confidence 0.19 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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