INT260145

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TGFBR2)
TGFBR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 62 99.56 Very High Very High Very High
Squamous Cell Carcinoma 61 98.92 Very High Very High Very High
Cancer 40 49.76 Quite Low
Lung Cancer 56 14.24 Low Low
Nicotine Addiction 11 6.48 Low Low
Small Cell Lung Cancer 8 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Non-small-cell Lung Cancer 2 5.00 Very Low Very Low Very Low
Small Cell Lung Carcinoma 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results support that both AD and SCC subtypes have suppressed TGF-beta signaling but through different mechanisms: in SCC there is increased expression of BMP7 that antagonizes TGF-beta functions [39], and reduced expression of TGFBR2, which suggests that SCC might be more sensitive than AD to targeting BMP7 or increasing expression of TGFBR2.
Positive_regulation (increasing) of Gene_expression (expression) of TGFBR2 associated with squamous cell carcinoma and adenocarcinoma
1) Confidence 0.45 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.04 Pain Relevance 0

General Comments

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