INT260148

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.71
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TGFBR2)
TGFBR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 2 100.00 Very High Very High Very High
palliative 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 142 99.84 Very High Very High Very High
Squamous Cell Carcinoma 122 99.12 Very High Very High Very High
Adenocarcinoma 126 98.64 Very High Very High Very High
Colorectal Cancer 100 86.84 High High
Lung Cancer 112 47.76 Quite Low
Small Cell Lung Cancer 16 47.36 Quite Low
Aging 2 40.60 Quite Low
Familial Adenomatous Polyposis 96 5.00 Very Low Very Low Very Low
Syndrome 76 5.00 Very Low Very Low Very Low
Polyps 70 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results support that both AD and SCC subtypes have suppressed TGF-beta signaling but through different mechanisms: in SCC there is increased expression of BMP7 that antagonizes TGF-beta functions [39], and reduced expression of TGFBR2, which suggests that SCC might be more sensitive than AD to targeting BMP7 or increasing expression of TGFBR2.
Negative_regulation (reduced) of Gene_expression (expression) of TGFBR2 associated with squamous cell carcinoma and adenocarcinoma
1) Confidence 0.38 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.07 Pain Relevance 0
In tumours where 4/5 of the CIMP panel were hypermethylated, they found a decrease in the expression of nuclear p27 and p53, as well as reduced expression of COX2 and increased TGFBR2 mutations.
Negative_regulation (reduced) of Gene_expression (expression) of TGFBR2 associated with cancer and cox2
2) Confidence 0.33 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.62 Pain Relevance 0.05
In tumours where 4/5 of the CIMP panel were hypermethylated, they found a decrease in the expression of nuclear p27 and p53, as well as reduced expression of COX2 and increased TGFBR2 mutations.
Negative_regulation (decrease) of Gene_expression (expression) of TGFBR2 associated with cancer and cox2
3) Confidence 0.33 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.64 Pain Relevance 0.05
Expression of the other two genes, FOS and TGFBR2, is reduced in tumor tissues, which is in agreement with the literature [26-28].
Negative_regulation (reduced) of Gene_expression (Expression) of TGFBR2 associated with cancer
4) Confidence 0.24 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.38 Pain Relevance 0

General Comments

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