INT260159

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.86
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PAG1) plasma membrane (PAG1) intracellular (PAG1)
Anatomy Link Frequency
projection neurons 2
PAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central grey 101 100.00 Very High Very High Very High
Rostral ventromedial medulla 51 100.00 Very High Very High Very High
Endocannabinoid 3 100.00 Very High Very High Very High
projection neuron 2 100.00 Very High Very High Very High
tolerance 14 99.84 Very High Very High Very High
Morphine 79 97.32 Very High Very High Very High
analgesia 25 95.92 Very High Very High Very High
midbrain 9 91.76 High High
medulla 8 90.72 High High
Pain 33 89.72 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 104 100.00 Very High Very High Very High
Stress 2 95.20 Very High Very High Very High
Pain 44 89.72 High High
Hypertension 1 10.16 Low Low
Heart Disease 1 8.24 Low Low
Hyperalgesia 9 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Inflammatory Pain 6 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
activation of the PAG-RVM projection neurons steadily declined in males only (see
Negative_regulation (declined) of Positive_regulation (activation) of PAG-RVM in projection neurons associated with projection neuron, central grey and rostral ventromedial medulla
1) Confidence 0.33 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 0.63 Pain Relevance 1.95
In the same study there was a relationship with the elevation of endocannabinoid levels in the PAG after injection of inhibitors of endocannabinoid degradation enzymes and an increase in tolerance to noxious stimuli.
Negative_regulation (inhibitors) of Positive_regulation (increase) of PAG associated with endocannabinoid, tolerance and central grey
2) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 1.23 Pain Relevance 1.45

General Comments

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