INT260172

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.53
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Rpe) carbohydrate metabolic process (Rpe)
Anatomy Link Frequency
retina 3
photoreceptor 1
neural retina 1
sclera 1
choroid 1
Rpe (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 42 98.44 Very High Very High Very High
alcohol 1 54.88 Quite High
cva 18 50.00 Quite Low
Eae 8 39.24 Quite Low
anesthesia 6 24.96 Low Low
Buprenorphine 2 20.56 Low Low
Analgesic 2 19.56 Low Low
Dopamine 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 260 99.56 Very High Very High Very High
Usher Syndrome 36 99.36 Very High Very High Very High
Geographic Atrophy 7 98.58 Very High Very High Very High
INFLAMMATION 51 98.44 Very High Very High Very High
Apoptosis 4 95.16 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 53 80.80 Quite High
Disease 25 69.64 Quite High
Ganglion Cysts 27 66.72 Quite High
Hypersensitivity 21 65.36 Quite High
Retina Disease 39 62.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 2 shows representative results obtained by culturing the RPE-choroid and retina of PER2::LUC mice.
Localization (retina) of RPE-choroid in retina
1) Confidence 0.49 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0
Therefore, to confirm the polarized localization of GPR109A to the basolateral membrane of RPE, we performed additional experiments.
Localization (localization) of RPE
2) Confidence 0.20 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0 Pain Relevance 0
The localization of the receptor to the RPE basolateral membrane places the receptor in a location conducive to its exposure to substrates in the choroidal circulation.
Localization (localization) of RPE
3) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0.06 Pain Relevance 0
To localize GPR109A protein in intact retina with respect to known markers of RPE apical and basolateral membranes, we employed immunofluorescent methods.
Localization (localize) of RPE in retina
4) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0.24 Pain Relevance 0
Immunofluorescence analysis of cryosections of intact mouse retina demonstrated localization of GPR109A protein exclusively in RPE, specifically in the basolateral membrane.
Localization (localization) of RPE in retina
5) Confidence 0.18 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0.07 Pain Relevance 0
Merging of positive signals for GPR109A and MCT1 did not result in any significant overlap, suggesting that these two proteins do not colocalize, and that GPR109A is localized to the basolateral membrane of the RPE.


Localization (membrane) of RPE
6) Confidence 0.18 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0.05 Pain Relevance 0
Figure 2 shows representative results obtained by culturing the RPE-choroid and retina of PER2::LUC mice.
Localization (retina) of RPE-choroid in choroid
7) Confidence 0.17 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0
RPE cells can also secrete different immune-suppressive and anti-inflammatory molecules as well as cell membrane-bound molecules, which can induce apoptosis of inflammatory cells and contribute to ocular immune privilege [11–14].
Localization (secrete) of RPE associated with inflammation and apoptosis
8) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2633462 Disease Relevance 0.29 Pain Relevance 0.10
Geographic atrophy, sometimes described as the end stage of dry AMD, is characterized by localized areas of RPE and neural retina degeneration without subretinal neovascularization.
Localization (localized) of RPE in neural retina associated with age-related macular degeneration and geographic atrophy
9) Confidence 0.14 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 2.12 Pain Relevance 0
USH proteins in the retina are generally thought to be localized to photoreceptor and/or RPE cells.
Localization (localized) of RPE in photoreceptor associated with usher syndrome
10) Confidence 0.10 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.70 Pain Relevance 0
All tissues (retina–RPE, choroid, pulverized sclera and extraocular muscle) were then homogenized in 1 ml TRIzol Reagent using a VirTis homogenizer (Gardiner, NY) before 5 min incubation at room temperature (RT) and 200 ?
Localization (retina) of RPE in sclera
11) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2671582 Disease Relevance 0 Pain Relevance 0.03

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