INT260285

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Context Info
Confidence 0.54
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.51
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F3) nucleus (E2F3) DNA binding (E2F3)
Anatomy Link Frequency
H69 2
E2F3 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 390 98.08 Very High Very High Very High
antagonist 2 13.00 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 189 99.86 Very High Very High Very High
Ovarian Cancer 126 97.94 Very High Very High Very High
Apoptosis 160 85.40 High High
Cancer 208 84.36 Quite High
Lung Cancer 30 71.12 Quite High
Infection 26 56.96 Quite High
Metastasis 6 45.96 Quite Low
Non-small-cell Lung Cancer 6 41.04 Quite Low
Genomic Instability 3 40.68 Quite Low
Retinoblastoma 3 34.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we assessed the activation status of five oncogenic signaling pathways in 157 ovarian tumor samples based on the activation observed in a mammalian cell line following tranfection of adenovirus expressing human c-Myc, activated H-Ras, human c-Src, human E2F3, or ?
Gene_expression (expressing) of E2F3 associated with ovarian cancer
1) Confidence 0.54 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.47 Pain Relevance 0
In this study we assessed the activation status of five oncogenic signaling pathways in 157 ovarian tumor samples based on the activation observed in a mammalian cell line following tranfection of adenovirus expressing human c-Myc, activated H-Ras, human c-Src, human E2F3, or ?
Gene_expression (human) of E2F3 associated with ovarian cancer
2) Confidence 0.46 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.46 Pain Relevance 0
E2F1, E2F2, E2F3, E2F4, E2F5 and E2F6 siRNAs were individually transfected in H69 cells.
Gene_expression (transfected) of E2F3 in H69
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.59 Pain Relevance 0.82
Control H69 SCLC cells contained E2F1, E2F2 and E2F3 bound to proliferative promoters.
Gene_expression (contained) of E2F3 in H69 associated with small cell lung cancer
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.57 Pain Relevance 0.31
Chemically synthesized, double-stranded siRNA for E2F1, E2F2, E2F3, E2F4, E2F5 and E2F6 was purchased from Santa Cruz Biotechnology.
Gene_expression (synthesized) of E2F3
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0 Pain Relevance 0
Other genes important for cell cycle progression, including E2F3 and TFDP2, are induced [32,33].
Gene_expression (progression) of E2F3
6) Confidence 0.22 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.41 Pain Relevance 0

General Comments

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