INT260296

Context Info Confidence 0.25 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.62 Pain Relevance 0.08

cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) cytosol (RASGRP1) lipid binding (RASGRP1)

RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Dopamine 2 80.24 ischemia 12 5.00 Catecholamine 3 5.00 Inflammation 2 5.00 opiate 1 5.00 Inflammatory response 1 5.00 abdominal pain 1 5.00 imagery 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Ovarian Cancer 63 97.44 Cancer 37 78.72 Apoptosis 3 53.12 Hyperemia 8 47.28 Sepsis 44 36.92 Fistula 1 18.24 Increased Venous Pressure Under Development 2 17.48 Cv Unclassified Under Development 11 5.00 Disease 8 5.00 Death 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Measurements of RAS activity

Negative_regulation (Measurements) of Gene_expression (activity) of RAS

1) Confidence 0.25 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0 Pain Relevance 0.08

Likewise, in our study, high expression of Ras inhibitor 1 (RIN1) and low expression of Ras-like without CAAX1 (RIT1) were associated with better overall survival, which is in agreement with previous work by others showing that activated Ras contributes to the maintenance and growth of ovarian carcinomas [38].

Negative_regulation (inhibitor) of Gene_expression (expression) of Ras associated with ovarian cancer

2) Confidence 0.05 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.62 Pain Relevance 0

General Comments

This test has worked.